一项关于分化型甲状腺癌患者经74MBq 131I诊断性全身扫描后甲状腺显影的定量研究。

A quantitative study about thyroid stunning after diagnostic whole-body scanning with 74 MBq 131I in patients with differentiated thyroid carcinoma.

作者信息

Yin Y, Mao Q, Chen S, Li N, Li X, Li Y

机构信息

Department of Nuclear Medicine, The First Hospital of China Medical University, China Medical University, Shenyang, China -

出版信息

Q J Nucl Med Mol Imaging. 2015 Dec;59(4):455-61.

PMID:26416037

Abstract

AIM

The aim of this paper was to explore by a quantitative method whether a 74 MBq 131I scanning activity produces a stunning effect in patients with differentiated thyroid carcinoma (DTC).

METHODS

We included 70 patients with DTC who had their first radioiodine treatment for ablation of thyroid remnants and/or metastases. All the patients received 1850~7400 MBq 131I. Before ablation, 34 patients (group A) performed a diagnostic scan (Dscan) 24 hours after the administration of 74 MBq 131I; 36 patients (group B) received 131I therapy without a previous Dscan. A therapeutic scan (Tscan) was performed after the ablation. The fractional concentrations of 131I in remnants or functional metastases were quantified on Dscan and Tscan, and were expressed as Dx and Tx respectively. The level of significance was set at 0.05.

RESULTS

For group A, 67 foci were found both on Dscan and Tscan, the mean Dx and Tx was 26.13±37.98 and 7.46±10.63 (P=0.000), respectively. For group B, 70 foci were found on Tscan, the mean Tx was 15.23±17.23, which was higher than group A significantly (P=0.002).

CONCLUSION

74 MBq 131I for diagnostic scan can decrease the uptake of 131I by thyroid remnants or metastases, the thyroid stunning exists.

摘要

目的

本文旨在通过定量方法探讨74MBq的131I扫描活度是否会对分化型甲状腺癌（DTC）患者产生顿抑效应。

方法

我们纳入了70例首次接受放射性碘治疗以消融甲状腺残余组织和/或转移灶的DTC患者。所有患者均接受了1850~7400MBq的131I。在消融前，34例患者（A组）在给予74MBq的131I后24小时进行了诊断性扫描（D扫描）；36例患者（B组）未进行D扫描而直接接受131I治疗。消融后进行了治疗性扫描（T扫描）。在D扫描和T扫描上对甲状腺残余组织或功能性转移灶中131I的分数浓度进行定量，并分别表示为Dx和Tx。显著性水平设定为0.05。