Phenylephrine Pharmacokinetics and First-Pass Metabolism: What Is an Ideal Pharmacokinetic Surrogate?

Suppr

超能文献

作者信息

Srinivas Nuggehally R

机构信息

Drug Development, Suramus Bio, 29th Main, 10th Cross, JP Nagar I Phase, Bangalore, Karnataka, 560078, India.

出版信息

Clin Drug Investig. 2015 Dec;35(12):851-3. doi: 10.1007/s40261-015-0341-3.

DOI:10.1007/s40261-015-0341-3

PMID:26416385

Abstract

摘要

相似文献

Phenylephrine Pharmacokinetics and First-Pass Metabolism: What Is an Ideal Pharmacokinetic Surrogate?

Clin Drug Investig. 2015 Dec;35(12):851-3. doi: 10.1007/s40261-015-0341-3.

Erratum to: Phenylephrine Pharmacokinetics and First-Pass Metabolism: What Is an Ideal Pharmacokinetic Surrogate?

Clin Drug Investig. 2015 Dec;35(12):855. doi: 10.1007/s40261-015-0353-z.

Pharmacokinetics, safety, and cardiovascular tolerability of phenylephrine HCl 10, 20, and 30 mg after a single oral administration in healthy volunteers.健康志愿者单次口服10毫克、20毫克和30毫克盐酸去氧肾上腺素后的药代动力学、安全性及心血管耐受性

Clin Drug Investig. 2015 Sep;35(9):547-58. doi: 10.1007/s40261-015-0311-9.

Pharmacokinetics of 3H-phenylephrine in man.

Eur J Clin Pharmacol. 1982;21(4):335-41. doi: 10.1007/BF00637623.

The phenylephrine concentration-response relationship for blood pressure after nasal delivery in children.儿童鼻腔给药后苯肾上腺素对血压的浓度-反应关系。

Paediatr Anaesth. 2017 Oct;27(10):1050-1055. doi: 10.1111/pan.13221. Epub 2017 Sep 4.

Increased bioavailability of phenylephrine by co-administration of acetaminophen: results of four open-label, crossover pharmacokinetic trials in healthy volunteers.对乙酰氨基酚与去氧肾上腺素联合给药提高去氧肾上腺素的生物利用度：四项健康志愿者开放标签、交叉药代动力学试验的结果

Eur J Clin Pharmacol. 2015 Feb;71(2):151-8. doi: 10.1007/s00228-014-1788-5. Epub 2014 Dec 6.

Ocular pharmacokinetics and pharmacodynamics of phenylephrine and phenylephrine oxazolidine in rabbit eyes.去氧肾上腺素和恶唑烷去氧肾上腺素在兔眼中的眼药代动力学和药效学

Pharm Res. 1990 May;7(5):476-83. doi: 10.1023/a:1015808514727.

Sustained Release Bilayer Tablet of Ibuprofen and Phenylephrine Hydrochloride: Preparation and Pharmacokinetics in Beagle Dogs.布洛芬和盐酸苯肾上腺素双层缓释片的制备及在比格犬体内的药代动力学研究。

AAPS PharmSciTech. 2019 Jan 23;20(2):86. doi: 10.1208/s12249-018-1271-1.

Mydriatic response to different concentrations of intracameral phenylephrine in humans.人眼房水中不同浓度苯肾上腺素的散瞳反应。

J Cataract Refract Surg. 2010 Oct;36(10):1682-6. doi: 10.1016/j.jcrs.2010.04.036.

The effect of reduced eyedrop size and eyelid closure on the therapeutic index of phenylephrine.

Am J Ophthalmol. 1993 Mar 15;115(3):357-9. doi: 10.1016/s0002-9394(14)73588-3.

本文引用的文献

Recent trends in preclinical drug-drug interaction studies of flavonoids--Review of case studies, issues and perspectives.黄酮类化合物临床前药物相互作用研究的最新趋势——病例研究、问题及展望综述

Phytother Res. 2015 Nov;29(11):1679-91. doi: 10.1002/ptr.5447. Epub 2015 Sep 6.

Clin Drug Investig. 2015 Sep;35(9):547-58. doi: 10.1007/s40261-015-0311-9.

Favipiravir inhibits acetaminophen sulfate formation but minimally affects systemic pharmacokinetics of acetaminophen.法匹拉韦抑制硫酸对乙酰氨基酚的形成，但对乙酰氨基酚的全身药代动力学影响极小。

Br J Clin Pharmacol. 2015 Nov;80(5):1076-85. doi: 10.1111/bcp.12644. Epub 2015 Jun 8.

Eur J Clin Pharmacol. 2015 Feb;71(2):151-8. doi: 10.1007/s00228-014-1788-5. Epub 2014 Dec 6.

Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples.柚皮素的个体 UDP-葡糖醛酸基转移酶和磺基转移酶及大鼠和人组织样品的 II 期代谢。

Drug Metab Dispos. 2010 Apr;38(4):617-25. doi: 10.1124/dmd.109.031047. Epub 2010 Jan 7.

Sulfation of budesonide by human cytosolic sulfotransferase, dehydroepiandrosterone-sulfotransferase (DHEA-ST).人胞质硫酸转移酶脱氢表雄酮硫酸转移酶（DHEA-ST）对布地奈德的硫酸化作用

Drug Metab Dispos. 2002 May;30(5):582-5. doi: 10.1124/dmd.30.5.582.

Pharmacokinetics of 3H-phenylephrine in man.

Eur J Clin Pharmacol. 1982;21(4):335-41. doi: 10.1007/BF00637623.

Ibopamine kinetics after a single oral dose in healthy volunteers.

Arzneimittelforschung. 1986 Feb;36(2A):345-8.

Dose-dependent pharmacokinetics and first-pass metabolism of acetaminophen in rats.对乙酰氨基酚在大鼠体内的剂量依赖性药代动力学及首过代谢

J Pharmacobiodyn. 1990 Jun;13(6):327-35. doi: 10.1248/bpb1978.13.327.

Pharmacokinetics of methyldopa in man.

J Pharmacol Exp Ther. 1976 Aug;198(2):264-77.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验