2013年和2014年马约特岛患者恶性疟原虫分离株中的K13螺旋桨多态性
K13-Propeller Polymorphisms in Plasmodium falciparum Isolates from Patients in Mayotte in 2013 and 2014.
作者信息
Torrentino-Madamet Marylin, Collet Louis, Lepère Jean François, Benoit Nicolas, Amalvict Rémy, Ménard Didier, Pradines Bruno
机构信息
Equipe Résidente de Recherche en Infectiologie Tropicale, Institut de Recherche Biomédicale des Armées, Hôpital d'Instruction des Armées, Marseille, France Aix Marseille Université, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM 63, CNRS 7278, IRD 198, Inserm 1095, Marseille, France Centre National de Référence du Paludisme, Marseille, France.
Laboratoire de Biologie, Centre Hospitalier de Mamoudzou, Mamoudzou, Mayotte, France.
出版信息
Antimicrob Agents Chemother. 2015 Dec;59(12):7878-81. doi: 10.1128/AAC.01251-15. Epub 2015 Sep 28.
Abstract
Plasmodium falciparum isolates were collected from 29 malaria patients treated with artemether-lumefantrine in Mayotte in 2013 and 2014. Twenty-four cases (83%) consisted of imported malaria. Seventeen percent of the isolates presented mutations in one of the six K13-propeller blades (N490H, F495L, N554H/K, and E596G). A total of 23.8% of the isolates from the Union of Comoros showed K13-propeller polymorphisms. Three of the 18 isolates (16.7%) from Grande Comore showed polymorphisms (N490H, N554K, and E596G).
摘要
2013年和2014年在马约特岛，从29例接受蒿甲醚-本芴醇治疗的疟疾患者身上采集了恶性疟原虫分离株。24例（83%）为输入性疟疾。17%的分离株在六个K13螺旋桨叶片之一中出现突变（N490H、F495L、N554H/K和E596G）。科摩罗联盟分离株中共有23.8%显示K13螺旋桨多态性。大科摩罗岛18株分离株中的3株（16.7%）显示多态性（N490H、N554K和E596G）。
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