Abid Kaouthar, Mili Donia, Kenani Abderraouf
Laboratory of Biochemistry, UR 12ES08, Faculty of Medicine, 5000 Monastir, Tunisia.
Dis Markers. 2015;2015:792679. doi: 10.1155/2015/792679. Epub 2015 Aug 31.
Multiple association studies found that the human 9p21.3 chromosome locus is a risk factor for atherosclerosis. The purpose of this study was to investigate the association of the severity and early-onset of coronary artery disease with variant rs1333049 on chromosome 9p21.3 polymorphism and the impact of this variant on cardiovascular risk factors in type 2 diabetic patients. The study population consisted of a control CAD group (101 patients) and 273 consecutive type 2 diabetic patients. Severity and extent of coronary atherosclerosis were scored numerically using the Gensini scoring system. The diabetic population was divided into three groups according to Gensini score: Group 1: no stenosis; Group 2: moderate CAD; Group 3, severe CAD. The homozygous CC genotype of rs1333049 was significantly associated with CAD in Group 2 (OR: 1.36; p = 0.02) and Group 3 (OR: 5.77, p < 0.001) compared to Group 1 (OR: 0.18; p = 0.2) and control group (OR: 0.22; p = 0.21). Among diabetic patients with early-onset CAD, CC genotype carriers had significantly higher Gensini scores than non-CC genotype carriers (49 ± 21.3 versus 14.87 ± 25.22; p < 0.001). The homozygous CC genotype of rs1333049 confers a magnified risk of early-onset and severe CAD in type 2 diabetic Tunisian population.
多项关联研究发现，人类9号染色体p21.3位点是动脉粥样硬化的一个风险因素。本研究的目的是调查9号染色体p21.3多态性位点rs1333049的变异与冠状动脉疾病的严重程度及早发之间的关联，以及该变异对2型糖尿病患者心血管危险因素的影响。研究人群包括一个对照冠心病组（101例患者）和273例连续入选的2型糖尿病患者。使用Gensini评分系统对冠状动脉粥样硬化的严重程度和范围进行数值评分。根据Gensini评分将糖尿病患者分为三组：第1组：无狭窄；第2组：中度冠心病；第3组：重度冠心病。与第1组（比值比：0.18；p = 0.2）和对照组（比值比：0.22；p = 0.21）相比，rs1333049的纯合CC基因型在第2组（比值比：1.36；p = 0.02）和第3组（比值比：5.77，p < 0.001）中与冠心病显著相关。在早发冠心病的糖尿病患者中，CC基因型携带者的Gensini评分显著高于非CC基因型携带者（49 ± 21.3对14.87 ± 25.22；p < 0.001）。rs1333049的纯合CC基因型在突尼斯2型糖尿病人群中赋予早发和重度冠心病更高的风险。
