CDKN2B 反义 RNA1（CDKN2B-AS1）rs1333049 多态性与斯洛文尼亚 2 型糖尿病患者心肌梗死的关联。
Association of Myocardial Infarction with CDKN2B Antisense RNA 1 (CDKN2B-AS1) rs1333049 Polymorphism in Slovenian Subjects with Type 2 Diabetes Mellitus.
机构信息
Department of Internal Medicine, General Hospital of Murska Sobota, Ul. dr. Vrbnjaka 6, 9000 Murska Sobota, Slovenia.
Department for Cardiology and Angiology, Clinic for Internal Medicine, University Medical Centre Maribor, 2000 Maribor, Slovenia.
出版信息
Genes (Basel). 2022 Mar 16;13(3):526. doi: 10.3390/genes13030526.
BACKGROUND
We examined the role of rs1333049 polymorphism of the CDKN2B Antisense RNA 1 (CDKN2B-AS1) on the prevalence of myocardial infarction (MI) in Slovenian subjects with type 2 diabetes mellitus (T2DM).
METHODS
A total of 1071 subjects with T2DM were enrolled in this retrospective cross-sectional case-control study. Of the subjects, 334 had a history of recent MI, and 737 subjects in the control group had no clinical signs of coronary artery disease (CAD). With logistic regression, we performed a genetic analysis of rs1333049 polymorphism in all subjects.
RESULTS
The C allele of rs1333049 polymorphism was statistically more frequent in MI subjects ( = 0.05). Subjects with CC genotype had a higher prevalence of MI than the control group in the co-dominant (AOR 1.50, CI 1.02-2.21, = 0.04) and recessive (AOR 1.38, CI 1.09-1.89, = 0.04) genetic model.
CONCLUSIONS
According to our study, the C allele and CC genotype of rs1333049 polymorphism of CDKN2B-AS1 are possible markers of MI in T2DM subjects in the Slovenian population.
背景
我们研究了 CDKN2B 反义 RNA1（CDKN2B-AS1）rs1333049 多态性在斯洛文尼亚 2 型糖尿病（T2DM）患者心肌梗死（MI）患病率中的作用。
方法
这项回顾性横断面病例对照研究共纳入 1071 例 T2DM 患者。其中 334 例有近期 MI 病史，737 例对照组无冠状动脉疾病（CAD）临床症状。通过 logistic 回归，我们对所有受试者的 rs1333049 多态性进行了遗传分析。
结果
rs1333049 多态性的 C 等位基因在 MI 患者中更为常见（ = 0.05）。与对照组相比，在共显性（AOR 1.50，CI 1.02-2.21， = 0.04）和隐性（AOR 1.38，CI 1.09-1.89， = 0.04）遗传模型中，CC 基因型患者 MI 患病率更高。
结论
根据我们的研究，CDKN2B-AS1 中的 rs1333049 多态性的 C 等位基因和 CC 基因型可能是斯洛文尼亚人群 T2DM 患者 MI 的标志物。
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