Michel Hilary, Olabopo Flora, Wang Li, Nucci Anita, Greenspan Susan L, Rajakumar Kumaravel
Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, United States.
Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, United States.
Curr Nutr Food Sci. 2015;11(2):124-130. doi: 10.2174/1573401311999150427164144.
Resurgence of rickets and recognition of excessive prevalence of hypovitaminosis D among all age groups in the western hemisphere have refocused attention on vitamin D nutrition.
To examine the prevalence of hypovitaminosis D [25-hydroxyvitamin D [25(OH)D] <30ng/mL] and characterize the determinants of 25(OH)D concentrations in 8- to 24-month-old healthy infants and toddlers living in Pittsburgh, Pennsylvania.
Serum 25(OH)D concentrations were measured and dietary intake of vitamin D, mode of feeding, summertime sun exposure characteristics, and skin color (sun-reactive skin type and melanin index) were assessed.
A total of 111 healthy 8- to 24-month-old children (mean age [±SD] 14.4 [±3.5] months; male, 51%; black, 67%) were studied. Serum 25(OH)D concentration was <30 ng/mL in 16% (n=18) of the children. Median (interquartile) 25(OH)D concentration was lower in children who were ≥ 13 months vs. <13 months of age [35 (31, 40.5) vs. 40 (35.8, 44.3) ng/mL, p=0.013]; with sun-reactive skin type IV and V vs. I, II, and III [36 (31, 41) vs. 44 (36.5, 48.5) ng/mL, p=0.001]; and examined during fall/winter vs. spring/summer [35.5 (32.5, 38.5) vs. 39 (32.5, 44) ng/mL, p=0.05]. Age and skin type were significant independent predictors of 25(OH)D.
Concentrations of 25(OH)D tend to be lower in infants and toddlers during fall/winter, and in children who are older (≥13 months vs. <13 months of age) and have darker skin tone. Benefits of enhancement of 25(OH)D concentrations during fall/winter and in children with higher sun-reactive skin type need further exploration.
佝偻病的再度出现以及西半球所有年龄组维生素D缺乏症患病率过高的情况，使人们重新将注意力集中在维生素D营养上。
研究宾夕法尼亚州匹兹堡市8至24个月健康婴幼儿维生素D缺乏症（25-羟维生素D [25(OH)D] <30 ng/mL）的患病率，并确定25(OH)D浓度的决定因素。
测量血清25(OH)D浓度，并评估维生素D的膳食摄入量、喂养方式、夏季阳光暴露特征和肤色（阳光反应性皮肤类型和黑色素指数）。
共研究了111名8至24个月的健康儿童（平均年龄[±标准差]14.4 [±3.5]个月；男性占51%；黑人占67%）。16%（n = 18）的儿童血清25(OH)D浓度<30 ng/mL。年龄≥13个月的儿童与<13个月的儿童相比，25(OH)D浓度中位数（四分位间距）较低[35（31，40.5）vs. 40（35.8，44.3）ng/mL，p = 0.013]；阳光反应性皮肤类型为IV型和V型的儿童与I型、II型和III型相比[
