• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Hydroxymethylation of DNA: an epigenetic marker.

作者信息

Richa Rajneesh, Sinha Rajeshwar P

机构信息

Laboratory of Photobiology and Molecular Microbiology, Centre of Advanced Study in Botany, Banaras Hindu University, Varanasi-221005, India.

出版信息

EXCLI J. 2014 May 27;13:592-610. eCollection 2014.

PMID:26417286
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4464262/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/737b/4464262/2f8ed6ecc5ee/EXCLI-13-592-g-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/737b/4464262/952d835da23e/EXCLI-13-592-t-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/737b/4464262/ab36a65e74c3/EXCLI-13-592-g-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/737b/4464262/c3abe565636e/EXCLI-13-592-g-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/737b/4464262/a116ab3f68d1/EXCLI-13-592-g-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/737b/4464262/2f8ed6ecc5ee/EXCLI-13-592-g-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/737b/4464262/952d835da23e/EXCLI-13-592-t-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/737b/4464262/ab36a65e74c3/EXCLI-13-592-g-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/737b/4464262/c3abe565636e/EXCLI-13-592-g-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/737b/4464262/a116ab3f68d1/EXCLI-13-592-g-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/737b/4464262/2f8ed6ecc5ee/EXCLI-13-592-g-004.jpg

相似文献

1
Hydroxymethylation of DNA: an epigenetic marker.DNA的羟甲基化:一种表观遗传标记。
EXCLI J. 2014 May 27;13:592-610. eCollection 2014.
2
Assessment of 'one-step' versus 'sequential' embryo culture conditions through embryonic genome methylation and hydroxymethylation changes.通过胚胎基因组甲基化和羟甲基化变化评估“一步法”与“序贯法”胚胎培养条件。
Hum Reprod. 2016 Nov;31(11):2471-2483. doi: 10.1093/humrep/dew214. Epub 2016 Sep 22.
3
Integrated analyses of multi-omics reveal global patterns of methylation and hydroxymethylation and screen the tumor suppressive roles of HADHB in colorectal cancer.多组学综合分析揭示了甲基化和羟甲基化的全局模式,并筛选出 HADHB 在结直肠癌中的肿瘤抑制作用。
Clin Epigenetics. 2018 Mar 2;10:30. doi: 10.1186/s13148-018-0458-3. eCollection 2018.
4
High Dietary Fat Intake Affects DNA Methylation/Hydroxymethylation in Mouse Heart: Epigenetic Hints for Obesity-Related Cardiac Dysfunction.高脂肪饮食摄入影响小鼠心脏的 DNA 甲基化/羟甲基化:肥胖相关心脏功能障碍的表观遗传学提示。
Mol Nutr Food Res. 2019 Feb;63(4):e1800970. doi: 10.1002/mnfr.201800970. Epub 2018 Dec 12.
5
DNA methylation/hydroxymethylation in melanoma.黑色素瘤中的DNA甲基化/羟甲基化
Oncotarget. 2017 May 30;8(44):78163-78173. doi: 10.18632/oncotarget.18293. eCollection 2017 Sep 29.
6
Effect of diabetes status and hyperglycemia on global DNA methylation and hydroxymethylation.糖尿病状态和高血糖对整体DNA甲基化和羟甲基化的影响。
Endocr Connect. 2017 Nov;6(8):708-725. doi: 10.1530/EC-17-0199. Epub 2017 Oct 9.
7
Role of TET Dioxygenases and DNA Hydroxymethylation in Bisphenols-Stimulated Proliferation of Breast Cancer Cells.TET 双加氧酶和 DNA 羟甲基化在双酚类物质刺激乳腺癌细胞增殖中的作用。
Environ Health Perspect. 2020 Feb;128(2):27008. doi: 10.1289/EHP5862. Epub 2020 Feb 27.
8
DNA methylation and hydroxymethylation in stem cells.干细胞中的DNA甲基化与羟甲基化
Cell Biochem Funct. 2015 Jun;33(4):161-73. doi: 10.1002/cbf.3101. Epub 2015 Mar 16.
9
TET enzymes and DNA hydroxymethylation in neural development and function - how critical are they?TET 酶与 DNA 羟甲基化在神经发育和功能中的作用——它们有多关键?
Genomics. 2014 Nov;104(5):334-40. doi: 10.1016/j.ygeno.2014.08.018. Epub 2014 Sep 6.
10
Global Methylation and Hydroxymethylation in DNA from Blood and Saliva in Healthy Volunteers.健康志愿者血液和唾液中DNA的整体甲基化和羟甲基化
Biomed Res Int. 2015;2015:845041. doi: 10.1155/2015/845041. Epub 2015 May 18.

引用本文的文献

1
Chemotherapy treatment alters DNA methylation patterns in the prefrontal cortex of female rat brain.化疗会改变雌性大鼠大脑前额叶皮质中的DNA甲基化模式。
Sci Rep. 2025 Jul 1;15(1):20681. doi: 10.1038/s41598-025-07419-2.
2
Oxidative Stress and Redox Imbalance: Common Mechanisms in Cancer Stem Cells and Neurodegenerative Diseases.氧化应激与氧化还原失衡:癌症干细胞和神经退行性疾病中的共同机制
Cells. 2025 Mar 29;14(7):511. doi: 10.3390/cells14070511.
3
LncRNAs Ride the Storm of Epigenetic Marks.长链非编码RNA置身于表观遗传标记的风暴之中。

本文引用的文献

1
TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation.TET1 控制中枢神经系统 5-甲基胞嘧啶羟化、活性 DNA 去甲基化、基因转录和记忆形成。
Neuron. 2013 Sep 18;79(6):1086-93. doi: 10.1016/j.neuron.2013.08.032.
2
Crystal structures of B-DNA dodecamer containing the epigenetic modifications 5-hydroxymethylcytosine or 5-methylcytosine.含有表观遗传修饰 5-羟甲基胞嘧啶或 5-甲基胞嘧啶的 B-DNA 十二聚体的晶体结构。
Nucleic Acids Res. 2013 Nov;41(21):9891-900. doi: 10.1093/nar/gkt738. Epub 2013 Aug 20.
3
Optical detection of epigenetic marks: sensitive quantification and direct imaging of individual hydroxymethylcytosine bases.
Genes (Basel). 2025 Mar 6;16(3):313. doi: 10.3390/genes16030313.
4
Effects of Environmental Non-Essential Toxic Heavy Metals on Epigenetics During Development.环境中非必需有毒重金属对发育过程中表观遗传学的影响。
Toxics. 2025 Feb 27;13(3):167. doi: 10.3390/toxics13030167.
5
Long-read metagenomic sequencing negates inferred loss of cytosine methylation in Myxosporea (Cnidaria: Myxozoa).长读长宏基因组测序否定了粘孢子虫(刺胞动物门:粘孢子纲)中胞嘧啶甲基化推断的缺失。
Gigascience. 2025 Jan 6;14. doi: 10.1093/gigascience/giaf014.
6
Epigenetics in Skin Homeostasis and Ageing.皮肤稳态与衰老中的表观遗传学
Epigenomes. 2025 Jan 9;9(1):3. doi: 10.3390/epigenomes9010003.
7
Identification of methylation-sensitive human transcription factors using meSMiLE-seq.使用meSMiLE-seq鉴定甲基化敏感的人类转录因子。
bioRxiv. 2024 Nov 12:2024.11.11.619598. doi: 10.1101/2024.11.11.619598.
8
The impact of the early environment on oxytocin receptor epigenetics and potential therapeutic implications.早期环境对催产素受体表观遗传学的影响及潜在治疗意义。
Pediatr Res. 2024 Nov 15. doi: 10.1038/s41390-024-03563-z.
9
DNA Methylation in Alzheimer's Disease.阿尔茨海默病中的DNA甲基化
Curr Top Behav Neurosci. 2025;69:149-178. doi: 10.1007/7854_2024_530.
10
Unraveling the Epigenetic Landscape: Insights into Parkinson's Disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis.解析表观遗传景观:对帕金森病、肌萎缩侧索硬化症和多发性硬化症的见解
Brain Sci. 2024 May 29;14(6):553. doi: 10.3390/brainsci14060553.
光学检测表观遗传标记:单个 5-羟甲基胞嘧啶碱基的灵敏定量和直接成像。
Chem Commun (Camb). 2013 Oct 7;49(77):8599-601. doi: 10.1039/c3cc42543f.
4
Dynamics of 5-hydroxymethylcytosine and chromatin marks in Mammalian neurogenesis.哺乳动物神经发生中 5-羟甲基胞嘧啶和染色质标记的动态变化。
Cell Rep. 2013 Feb 21;3(2):291-300. doi: 10.1016/j.celrep.2013.01.011. Epub 2013 Feb 9.
5
MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system.MECP2 与神经系统中富含 5hmC 的活跃基因和可及染色质结合。
Cell. 2012 Dec 21;151(7):1417-30. doi: 10.1016/j.cell.2012.11.022.
6
Genome-wide DNA hydroxymethylation changes are associated with neurodevelopmental genes in the developing human cerebellum.全基因组 DNA 羟甲基化变化与发育中人类小脑的神经发育基因有关。
Hum Mol Genet. 2012 Dec 15;21(26):5500-10. doi: 10.1093/hmg/dds394. Epub 2012 Oct 5.
7
5-Hydroxymethylcytosine--the elusive epigenetic mark in mammalian DNA.5-羟甲基胞嘧啶——哺乳动物 DNA 中难以捉摸的表观遗传标记。
Chem Soc Rev. 2012 Nov 7;41(21):6916-30. doi: 10.1039/c2cs35104h. Epub 2012 Jul 27.
8
5-Methylcytosine and 5-hydroxymethylcytosine spatiotemporal profiles in the mouse zygote.小鼠受精卵中 5-甲基胞嘧啶和 5-羟甲基胞嘧啶的时空分布
PLoS One. 2012;7(5):e38156. doi: 10.1371/journal.pone.0038156. Epub 2012 May 31.
9
Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.哺乳动物基因组中 5-羟甲基胞嘧啶的碱基分辨率分析。
Cell. 2012 Jun 8;149(6):1368-80. doi: 10.1016/j.cell.2012.04.027. Epub 2012 May 17.
10
Tet family proteins and 5-hydroxymethylcytosine in development and disease.Tet 家族蛋白与 5-羟甲基胞嘧啶在发育和疾病中的作用。
Development. 2012 Jun;139(11):1895-902. doi: 10.1242/dev.070771.