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1
In vitro test systems and their limitations.体外测试系统及其局限性。
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2
Toxicogenomics directory of chemically exposed human hepatocytes.化学暴露人肝细胞毒代基因组学目录。
Arch Toxicol. 2014 Dec;88(12):2261-87. doi: 10.1007/s00204-014-1400-x. Epub 2014 Nov 16.
3
Bridging the gap between metabolic liver processes and functional tissue structure by integrated spatiotemporal modeling applied to hepatic ammonia detoxification.通过应用于肝脏氨解毒的综合时空建模弥合代谢肝脏过程与功能组织结构之间的差距。
Hepatology. 2014 Dec;60(6):1823-5. doi: 10.1002/hep.27364. Epub 2014 Nov 3.
4
How predictive quantitative modelling of tissue organisation can inform liver disease pathogenesis.如何通过对组织的定量预测模型来了解肝脏疾病的发病机制。
J Hepatol. 2014 Oct;61(4):951-6. doi: 10.1016/j.jhep.2014.06.013. Epub 2014 Jun 17.
5
Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis.人、小鼠和猪肝脏胆小管和肝血窦网络染色方案、通过图像处理和分析进行组织微结构的三维重建和定量分析。
Arch Toxicol. 2014 May;88(5):1161-83. doi: 10.1007/s00204-014-1243-5. Epub 2014 Apr 19.
6
Integrated metabolic spatial-temporal model for the prediction of ammonia detoxification during liver damage and regeneration.用于预测肝损伤和再生期间氨解毒的综合代谢时空模型。
Hepatology. 2014 Dec;60(6):2040-51. doi: 10.1002/hep.27136. Epub 2014 May 12.
7
Chronic CCl4 intoxication causes liver and bone damage similar to the human pathology of hepatic osteodystrophy: a mouse model to analyse the liver-bone axis.慢性四氯化碳中毒可引起肝和骨损伤，类似于人类肝性骨营养不良的病理变化：一种用于分析肝-骨轴的小鼠模型。
Arch Toxicol. 2014 Apr;88(4):997-1006. doi: 10.1007/s00204-013-1191-5. Epub 2014 Jan 1.
8
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.近年来，利用原代肝细胞、替代的肝细胞来源和非实质细胞的 2D 和 3D 体外系统在研究肝毒性、细胞信号转导和 ADME 的机制方面取得了进展。
Arch Toxicol. 2013 Aug;87(8):1315-530. doi: 10.1007/s00204-013-1078-5. Epub 2013 Aug 23.
9
A special issue about hepatotoxicity and hepatocyte in vitro systems.关于肝毒性和体外肝细胞系统的特刊。
Arch Toxicol. 2013 Aug;87(8):1313-4. doi: 10.1007/s00204-013-1092-7.
10
Hepatic 3D cultures but not 2D cultures preserve specific transporter activity for acetaminophen-induced hepatotoxicity.肝 3D 培养物而非 2D 培养物可保留对乙酰氨基酚诱导肝毒性的特定转运体活性。
Arch Toxicol. 2013 Aug;87(8):1581-93. doi: 10.1007/s00204-013-1080-y. Epub 2013 Jun 1.

Integrated spatiotemporal-metabolic modelling bridges the gap between metabolism on the cellular level and organ function.

作者信息

Widera Agata

机构信息

Leibniz Institut für Arbeitsforschung an der TU Dortmund, Leibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystrasse 67, 44139 Dortmund, Germany.

出版信息

EXCLI J. 2014 Dec 17;13:1289-91. eCollection 2014.

PMID:26417345
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4464484/
Abstract
摘要