A meta-analysis of individual data for 6756 patients showed that intravenous thrombolysis with alteplase improved survival without overt neurological deficits when started within 4.5 hours of the first symptoms of ischaemic stroke, at a cost of increased mortality due to cerebral haemorrhage during the week following thrombolysis.
一项对6756例患者个体数据的荟萃分析表明,在缺血性卒中首次症状出现后的4.5小时内开始使用阿替普酶进行静脉溶栓,可提高无明显神经功能缺损的生存率,但代价是溶栓后一周内脑出血导致的死亡率增加。