PRC1 蛋白调控三维基因组结构。
PRC1 proteins orchestrate three-dimensional genome architecture.
机构信息
Institute of Human Genetics, UPR 1142, CNRS, Montpellier, France.
出版信息
Nat Genet. 2015 Oct;47(10):1105-6. doi: 10.1038/ng.3411.
DOI:10.1038/ng.3411
PMID:26417860
Abstract
The three-dimensional organization of the genome has an important role in orchestrating gene expression, but its regulation is poorly understood. Now, a new study uncovers a major role for Polycomb components of the PRC1 complex in organizing physical networks of genes that are co-repressed to maintain pluripotency.
摘要
基因组的三维组织在调控基因表达中具有重要作用，但它的调控机制还知之甚少。现在，一项新的研究揭示了 PRC1 复合物中的多梳成分在组织共同抑制以维持多能性的基因物理网络方面的重要作用。
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