育亨宾和氯氮卓的行为效应：取决于大鼠先前对测试条件的熟悉程度。
Behavioral effects of yohimbine and chlordiazepoxide: dependence on the rat's previous familiarization with the test conditions.
作者信息
Gentsch C, Lichteiner M, Feer H
机构信息
Psychiatric University Clinic Basle, Biochemical Laboratory, Switzerland.
出版信息
Neuropsychobiology. 1989;22(2):101-7. doi: 10.1159/000118601.
The effects of yohimbine and chlordiazepoxide on locomotor activity in an open field were found to depend on the rat's previous habituation to the test environment: chlordiazepoxide induced a locomotor activation in nonhabituated, but not in habituated rats; yohimbine activated in habituated rats only. In a further study, carried out in the rat's homecage (habituated conditions), the effect of both drugs on competition for sucrose pellets was assessed: yohimbine, but not chlordiazepoxide, helped so-called poor-performing rats to temporarily overcome their typical abstention from competition. The presence or absence of drug effects, obviously depending on the rat's previous familiarization with the test environment, are discussed with view to Gray's concept of the behavioral inhibition system.
育亨宾和氯氮卓对旷场中运动活动的影响被发现取决于大鼠先前对测试环境的适应情况
氯氮卓在未适应的大鼠中诱导运动激活，但在适应的大鼠中则不然；育亨宾仅在适应的大鼠中产生激活作用。在另一项在大鼠饲养笼（适应条件）中进行的研究中，评估了两种药物对蔗糖颗粒竞争的影响：育亨宾而非氯氮卓帮助所谓表现不佳的大鼠暂时克服了它们典型的竞争回避行为。考虑到格雷的行为抑制系统概念，对明显取决于大鼠先前对测试环境熟悉程度的药物效应的有无进行了讨论。
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