氯氮䓬对探索习惯化的影响：与苯二氮䓬拮抗剂RO 15-1788的相互作用。
The effect of chlordiazepoxide on the habituation of exploration: interactions with the benzodiazepine antagonist RO 15-1788.
作者信息
Lister R G, File S E
出版信息
Pharmacol Biochem Behav. 1987 Mar;26(3):631-4. doi: 10.1016/0091-3057(87)90177-8.
Rats tested on two occasions in a holeboard apparatus showed between-session habituation of exploratory activity. No habituation was observed on the measure of locomotor activity. Administration of chlordiazepoxide before the first test reduced exploratory behavior in this test and also reduced the degree of between-session habituation. Administration of RO 15-1788 reversed the effect of chlordiazepoxide on exploration in the first test, but failed to reverse the drug's effect on between-session habituation. It is unlikely that state-dependent retrieval could account for these results. The results are discussed in relation to the effects of benzodiazepines on learning and memory.
在洞板装置中接受两次测试的大鼠表现出两次测试之间探索活动的习惯化。在运动活动测量中未观察到习惯化。在首次测试前给予氯氮卓减少了该测试中的探索行为，也降低了两次测试之间的习惯化程度。给予RO 15 - 1788在首次测试中逆转了氯氮卓对探索的影响，但未能逆转该药物对两次测试之间习惯化的影响。状态依赖性检索不太可能解释这些结果。结合苯二氮卓类药物对学习和记忆的影响对结果进行了讨论。
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