血清紫藤凝集素阳性Mac-2结合蛋白及血清干扰素-γ诱导蛋白10在原发性胆汁性肝硬化中的作用
Impact of serum Wisteria floribunda agglutinin positive Mac-2-binding protein and serum interferon-γ-inducible protein-10 in primary biliary cirrhosis.
作者信息
Nishikawa Hiroki, Enomoto Hirayuki, Iwata Yoshinori, Hasegawa Kunihiro, Nakano Chikage, Takata Ryo, Nishimura Takashi, Yoh Kazunori, Aizawa Nobuhiro, Sakai Yoshiyuki, Ikeda Naoto, Takashima Tomoyuki, Ishii Akio, Iijima Hiroko, Nishiguchi Shuhei
机构信息
Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan.
出版信息
Hepatol Res. 2016 May;46(6):575-83. doi: 10.1111/hepr.12595. Epub 2015 Nov 5.
AIM
We aimed to examine the relationship between serum Wisteria floribunda agglutinin positive Mac-2-binding protein (WFA(+) -M2BP) levels and serum interferon-γ-inducible protein-10 (IP-10) levels and liver histological findings for patients with primary biliary cirrhosis (PBC) compared with other laboratory fibrotic or inflammatory parameters.
METHODS
A total of 57 PBC patients were analyzed. Receiver-operator curve (ROC) analysis was performed for calculating the area under the ROC (AUROC) for WFA(+) -M2BP, IP-10 and four serum fibrosis markers for the presence of liver cirrhosis (F4) or advanced fibrosis (F3 or F4). Similarly, ROC analysis of WFA(+) -M2BP, IP-10, aspartate aminotransferase and alanine aminotransferase for the presence of severe inflammation activity (A3) was performed.
RESULTS
There were eight men and 49 women (median age, 59 years). As for histological findings, F4 was observed in five patients, F3 in 11, F2 in 17, F1 in 24 and F0 in zero, whereas A3 was observed in seven patients, A2 in 27, A1 in 19 and A0 in four. The WFA(+) -M2BP levels ranged from 0.5 cut-off index (COI) to 13.6 COI (median, 1.8), while serum IP-10 levels ranged 121.9-1835.9 pg/mL (median, 571.5). For predicting liver cirrhosis, WFA(+) -M2BP yielded the highest AUROC (0.97, P < 0.01). For predicting severe liver inflammation activity (A3), WFA(+) -M2BP and serum IP-10 yielded the highest AUROC with a level of 0.87. WFA(+) -M2BP levels significantly correlated with serum IP-10 levels (rs = 0.55, P < 0.0001).
CONCLUSION
Serum WFA(+) -M2BP and serum IP-10 can be useful markers for predicting histological findings in PBC patients.
目的
我们旨在研究原发性胆汁性肝硬化（PBC）患者血清紫藤凝集素阳性Mac-2结合蛋白（WFA(+) -M2BP）水平与血清干扰素-γ诱导蛋白10（IP-10）水平之间的关系，以及与肝脏组织学结果的关系，并与其他实验室纤维化或炎症参数进行比较。
方法
共分析了57例PBC患者。进行了受试者操作特征曲线（ROC）分析，以计算WFA(+) -M2BP、IP-10和四种血清纤维化标志物用于诊断肝硬化（F4）或进展期纤维化（F3或F4）时的ROC曲线下面积（AUROC）。同样，对WFA(+) -M2BP、IP-10、天冬氨酸转氨酶和丙氨酸转氨酶用于诊断严重炎症活动（A3）进行了ROC分析。
结果
有8名男性和49名女性（中位年龄59岁）。组织学结果方面，5例患者为F4，11例为F3，17例为F2，24例为F1，0例为F0；而7例患者为A3，27例为A2，19例为A1，4例为A0。WFA(+) -M2BP水平范围为0.5临界指数（COI）至13.6 COI（中位值1.8），血清IP-10水平范围为121.9 - 1835.9 pg/mL（中位值571.5）。对于预测肝硬化，WFA(+) -M2BP的AUROC最高（0.97，P < 0.01）。对于预测严重肝脏炎症活动（A3），WFA(+) -M2BP和血清IP-10的AUROC最高，为0.87。WFA(+) -M2BP水平与血清IP-10水平显著相关（rs = 0.55，P < 0.0001）。
结论
血清WFA(+) -M2BP和血清IP-10可作为预测PBC患者组织学结果的有用标志物。
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