Dierssen M, Flórez J, Hurlé M A
Departamento de Fisiología y Farmacología, Facultad de Medicina, Universidad de Cantabria, Santander, Spain.
Rev Esp Fisiol. 1989;45 Suppl:185-90.
The present study investigates the interaction between CCK and opioid systems on the central control of breathing by analyzing the respiratory effects of CCK-8S (0.09 nmol) and met-enkephalin (0.7 and 1.4 mumol) applied to the ventral medullary surface of cats under the influence of the opiate antagonist naloxone and the CCK antagonist proglumide. Neither naloxone nor proglumide were able to modify the respiratory effects of CCK-8S and met-enkephalin, respectively. Therefore, the hypothesis that CCK and the opioid systems might operate as parallel and antagonic forces throughout the central nervous system, is no longer tenable.
本研究通过分析在阿片拮抗剂纳洛酮和CCK拮抗剂丙谷胺影响下，将CCK-8S（0.09纳摩尔）和甲硫氨酸脑啡肽（0.7和1.4微摩尔）应用于猫延髓腹侧面时的呼吸效应，来研究CCK和阿片系统在呼吸中枢控制方面的相互作用。纳洛酮和丙谷胺均不能分别改变CCK-8S和甲硫氨酸脑啡肽的呼吸效应。因此，CCK和阿片系统可能在整个中枢神经系统中作为平行且拮抗的力量发挥作用这一假设不再成立。
