McRoberts J W
Anesth Prog. 1986 Mar-Apr;33(2):87-90.
The recent discovery that cholecystokinin (CCK) is present in the nervous system has prompted studies that have nearly proven its neurotransmitter status. Pain modulation appears to be a major effect of CCK and proglumide, its antagonist. CCK's inhibitory effect and proglumide's potentiating effect on opiate analgesia may have clinical application; proglumide's inhibitory effect on opiate tolerance may help in management of chronic pain. More research is required before the CCK/opiate interaction can be exploited on a large scale to relieve pain.
最近发现胆囊收缩素（CCK）存在于神经系统中，这促使了一些研究，这些研究几乎证实了它的神经递质地位。疼痛调节似乎是CCK及其拮抗剂丙谷胺的主要作用。CCK对阿片类镇痛的抑制作用以及丙谷胺的增强作用可能具有临床应用价值；丙谷胺对阿片类耐受性的抑制作用可能有助于慢性疼痛的管理。在大规模利用CCK/阿片类相互作用来缓解疼痛之前，还需要更多的研究。
