动力蛋白-5：一个团队只是其各个部分的总和。

Kinesin-5: A Team Is Just the Sum of Its Parts.

机构信息

Department of Cell & Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.

Department of Cell & Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA; Tetrad Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.

出版信息

Dev Cell. 2015 Sep 28;34(6):609-10. doi: 10.1016/j.devcel.2015.09.010.

DOI:10.1016/j.devcel.2015.09.010

PMID:26418291

Abstract

How the cell builds a spindle remains an open question. In this issue of Developmental Cell, Shimamoto, Forth, and Kapoor (2015) show that kinesin-5 motor ensembles can exert sliding forces that scale with microtubule overlap length. This behavior could allow microtubule architecture-dependent modulation of force and contribute to spindle self-organization.

摘要

细胞如何构建纺锤体仍然是一个悬而未决的问题。在本期《发育细胞》杂志中，Shimamoto、Forth 和 Kapoor（2015）表明驱动蛋白-5 运动复合物可以产生与微管重叠长度成比例的滑动力。这种行为可能允许依赖于微管结构的力的调节，并有助于纺锤体的自我组织。