Torres-Sánchez Irene, Valenza Marie Carmen, Sáez-Roca Germán, Cabrera-Martos Irene, López-Torres Isabel, Rodríguez-Torres Jeanette
a Department of Physical Therapy, School of Health Sciences . University of Granada , Spain.
b Pulmonary Medicine Service , Virgen de las Nieves University Hospital, Granada, Andalusian Health Service , Spain.
COPD. 2016;13(1):19-25. doi: 10.3109/15412555.2015.1043428. Epub 2015 Sep 29.
The objective of this study was to analyze the results of a multimodal therapeutic program during hospitalization in obese AECOPD patients. This was a randomized, single-blind clinical trial conducted at two university hospitals in Granada, Spain. Forty-nine patients hospitalized due to AECOPD were randomly allocated to a control group (CG), in which patients received standard care, or to an intervention group (IG), in which patients were included in a multimodal therapeutic program, added to the standard care. The main outcome measures were pulmonary, physical (strength and exercise capacity) and perceived (dyspnea, quality of life and psychological distress) variables. Within-group significant improvements (p < 0.05) were found in physical and perceived variables in the IG after the treatment. In the CG, a significant decrease was found in lower limb strength and a significant improvement in dyspnea and in three subscales of the EuroQol-5D questionnaire. The between-groups analysis showed significant differences after the treatment on lower limb strength and exercise capacity values (p < 0.05), in three of the EuroQol-5D subscales, and in the total score and the depression subscale of the Hospital Anxiety and Depression Scale. A multimodal therapeutic program has a beneficial effect on physical functioning and perceived variables in hospitalized obese patients with AECOPD.
本研究的目的是分析肥胖慢性阻塞性肺疾病急性加重期（AECOPD）患者住院期间多模式治疗方案的效果。这是一项在西班牙格拉纳达的两家大学医院进行的随机、单盲临床试验。49例因AECOPD住院的患者被随机分配至对照组（CG），该组患者接受标准治疗，或分配至干预组（IG），该组患者在接受标准治疗的基础上被纳入多模式治疗方案。主要结局指标为肺部、身体（力量和运动能力）和感知（呼吸困难、生活质量和心理困扰）变量。治疗后，干预组的身体和感知变量在组内有显著改善（p < 0.05）。在对照组中，下肢力量显著下降，呼吸困难以及欧洲五维健康量表（EuroQol-5D）问卷的三个子量表有显著改善。组间分析显示，治疗后下肢力量和运动能力值（p < 0.05）、EuroQol-5D问卷的三个子量表、医院焦虑抑郁量表的总分及抑郁子量表存在显著差异。多模式治疗方案对肥胖AECOPD住院患者的身体功能和感知变量有有益影响。
