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[肛管表皮样癌。多学科方法的价值]

[Epidermoid carcinoma of the anal canal. Value of a multidisciplinary approach].

作者信息

Marti M C, Pipard G

出版信息

Chirurgie. 1989;115(10):717-22.

PMID:2641929
Abstract

Great progress has been achieved in the clinical diagnosis, the pathologic patterns study and the treatment of anal epidermoid carcinomas. External and interstitial radiotherapy in association with chemotherapy offers today a real chance to cure these lesions and to save sphincter function. Incidence in actinic lesions is reduced. Salvage abdominoperineal excision is still possible in case of local recurrence without delay in wound healing. 95 cases of anal epidermoid carcinoma were treated in the University cantonal Hospital of Geneva by a combined radio-chemotherapy approach. Local control has been achieved in 86% of tumors less than 4 cm in diameter and 73% of tumors more than 4 cm in diameter. Salvage abdomino-perineal excision has been required in 10% of cases. Abdomino-perineal excision is no more the first treatment of choice of anal epidermoid carcinoma.

摘要

肛管表皮样癌在临床诊断、病理模式研究及治疗方面均取得了巨大进展。如今,外照射放疗和组织间插植放疗联合化疗为治愈这些病变及保留括约肌功能提供了切实机会。光化性病变的发病率有所降低。若出现局部复发且伤口愈合无延迟,挽救性腹会阴切除术仍可行。日内瓦州立大学医院采用放化疗联合方法治疗了95例肛管表皮样癌。直径小于4厘米的肿瘤局部控制率达86%,直径大于4厘米的肿瘤局部控制率为73%。10%的病例需要进行挽救性腹会阴切除术。腹会阴切除术不再是肛管表皮样癌的首选治疗方法。

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