[关于“祖贝尔”泉的克里尼察矿泉水对大鼠酒精损伤胃黏膜影响的研究]
[Studies on the effect of Krynica mineral water from the "Zuber" spring on alcohol-damaged gastric mucosa in rats].
作者信息
Mach T, Bogdał J, Stachura J, Kirchmayer S, Konturek J, Tetnowski J
出版信息
Folia Med Cracov. 1989;30(1-2):63-9.
The study was performed to investigate the protective effect of mineral water "Zuber", "Zuber" with "Jan" and an antacid on the alcohol induced gastric mucosal injury in rats. It was shown that Alugastrin, a hyperosmotic liquid antacid, protects rat gastric mucosa against alcohol. In opposite, a hyperosmotic and alkaline mineral water "Zuber" increases a vulnerability of the gastric mucosa and worsen the damaging effect of alcohol on it. Izoosmotic mixture of mineral waters "Zuber" and "Jan", similarly to a physiologic saline, do not protect rat gastric mucosa. The study show that mineral waters "Zuber" and "Zuber" with "Jan" have a short-lasting neutralizing effect on the gastric HCl and in opposite to antacids have not protective properties on gastric mucosa.
本研究旨在探讨矿泉水“祖贝”、“祖贝”与“扬”的混合液以及一种抗酸剂对大鼠酒精性胃黏膜损伤的保护作用。结果表明，高渗液体抗酸剂阿卢胃泌素可保护大鼠胃黏膜免受酒精损伤。相反，高渗碱性矿泉水“祖贝”会增加胃黏膜的易损性，并加重酒精对其的损伤作用。“祖贝”与“扬”的等渗混合矿泉水，与生理盐水类似，不能保护大鼠胃黏膜。研究表明，矿泉水“祖贝”以及“祖贝”与“扬”的混合液对胃内盐酸有短暂的中和作用，且与抗酸剂不同，对胃黏膜没有保护作用。
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