Activating somatic mutations outside the SH2-domain of STAT3 in LGL leukemia.
作者信息
Andersson E, Kuusanmäki H, Bortoluzzi S, Lagström S, Parsons A, Rajala H, van Adrichem A, Eldfors S, Olson T, Clemente M J, Laasonen A, Ellonen P, Heckman C, Loughran T P, Maciejewski J P, Mustjoki S
机构信息
Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland.
Department of Hematology, Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland.
出版信息
Leukemia. 2016 May;30(5):1204-8. doi: 10.1038/leu.2015.263. Epub 2015 Sep 30.
Abstract
摘要
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本文引用的文献
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Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells.源自γδ-T细胞或NK细胞的淋巴瘤中STAT5B和STAT3的激活突变。
Nat Commun. 2015 Jan 14;6:6025. doi: 10.1038/ncomms7025.
2
Immunosuppressive therapy of LGL leukemia: prospective multicenter phase II study by the Eastern Cooperative Oncology Group (E5998).大颗粒淋巴细胞白血病的免疫抑制治疗：东部肿瘤协作组（E5998）的前瞻性多中心II期研究
Leukemia. 2015 Apr;29(4):886-94. doi: 10.1038/leu.2014.298. Epub 2014 Sep 13.
3
Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease.信号转导及转录激活因子3（STAT3）的种系激活突变会导致早发性多器官自身免疫性疾病。
Nat Genet. 2014 Aug;46(8):812-814. doi: 10.1038/ng.3040. Epub 2014 Jul 20.
4
STAT3 mutations are present in aggressive B-cell lymphomas including a subset of diffuse large B-cell lymphomas with CD30 expression.STAT3突变存在于侵袭性B细胞淋巴瘤中，包括一部分表达CD30的弥漫性大B细胞淋巴瘤。
Haematologica. 2014 Jul;99(7):e105-7. doi: 10.3324/haematol.2013.101543. Epub 2014 May 16.
5
Arginine residues within the DNA binding domain of STAT3 promote intracellular shuttling and phosphorylation of STAT3.信号转导和转录激活因子3（STAT3）DNA结合域内的精氨酸残基促进STAT3的细胞内穿梭和磷酸化。
Cell Signal. 2014 Aug;26(8):1698-706. doi: 10.1016/j.cellsig.2014.03.033. Epub 2014 Apr 8.
6
A novel missense (M206K) STAT3 mutation in diffuse large B cell lymphoma deregulates STAT3 signaling.弥漫性大 B 细胞淋巴瘤中一种新型错义突变（M206K）STAT3 导致 STAT3 信号通路失调。
PLoS One. 2013 Jul 4;8(7):e67851. doi: 10.1371/journal.pone.0067851. Print 2013.
7
Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia.大颗粒淋巴细胞白血病中体细胞 STAT5b 突变的发现。
Blood. 2013 May 30;121(22):4541-50. doi: 10.1182/blood-2012-12-474577. Epub 2013 Apr 17.
8
STAT3 mutations are frequent in CD30+ T-cell lymphomas and T-cell large granular lymphocytic leukemia.信号转导和转录激活因子3（STAT3）突变在CD30+ T细胞淋巴瘤和T细胞大颗粒淋巴细胞白血病中很常见。
Leukemia. 2013 Nov;27(11):2244-7. doi: 10.1038/leu.2013.104. Epub 2013 Apr 8.
9
STAT3 mutations are highly specific for large granular lymphocytic leukemia.信号转导和转录激活因子3（STAT3）突变对大颗粒淋巴细胞白血病具有高度特异性。
Leukemia. 2013 Jul;27(7):1598-600. doi: 10.1038/leu.2012.350. Epub 2012 Dec 4.
10
STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia.STAT3 突变使 NK 细胞慢性淋巴增殖性疾病和 T 细胞大颗粒淋巴细胞白血病的发病机制趋于统一。
Blood. 2012 Oct 11;120(15):3048-57. doi: 10.1182/blood-2012-06-435297. Epub 2012 Aug 2.
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