Zou Wei, Wang Jiajun, Hu Danfeng, Wang Wenxia
School of Electronic and Information Engineering, Soochow University, Suzhou, 215006, China.
Department of Electronic and Information Engineering, Hong Kong Polytechnic University, Kowloon, Hong Kong.
Biomed Eng Online. 2015 Sep 30;14:86. doi: 10.1186/s12938-015-0080-y.
Fluorescent molecular tomography (FMT) aims at reconstructing the spatial map of optical and fluorescence parameters from fluence measurements. Basically, solving large-scale matrix equations is computationally expensive for image reconstruction of FMT. Despite the reconstruction quality can be improved with more sources, it may result in higher computational costs for reconstruction. This article presents a novel method in the wavelet domain with rotated sources illumination.
We use the finite element method for the computation of the forward model. The global inverse problem is solved based on wavelet in conjunction with principal component analysis. The iterative reconstruction is implemented with sources rotated in a certain angle. The original excitation light sources are used to reconstruct the image in the first iteration. Then, upon the sources are rotated by a certain angle, they are employed for the next iteration of reconstruction.
Simulation results demonstrate that our method can considerably reduce the time taken for the computation of inverse problem in FMT. Furthermore, the approach proposed is also shown to largely outperform the traditional method in terms of the precision of inverse solutions.
Our method has the capability to locate the inclusions. The proposed method can significantly speed up the reconstruction process with the high reconstruction quality.
荧光分子断层成像（FMT）旨在根据通量测量重建光学和荧光参数的空间分布图。基本上，求解大规模矩阵方程对于FMT的图像重建来说计算成本很高。尽管增加光源数量可以提高重建质量，但这可能会导致更高的重建计算成本。本文提出了一种在小波域中采用旋转光源照明的新方法。
我们使用有限元法计算正向模型。基于小波结合主成分分析来解决全局逆问题。通过以一定角度旋转光源来实现迭代重建。在第一次迭代中使用原始激发光源重建图像。然后，当光源旋转一定角度后，将其用于下一次迭代重建。
模拟结果表明，我们的方法可以显著减少FMT中逆问题的计算时间。此外，所提出的方法在逆解精度方面也大大优于传统方法。
我们的方法能够定位内含物。所提出的方法可以在保证高重建质量的同时显著加快重建过程。
