Petrusic I, Podgorac A, Zidverc-Trajkovic J, Radojicic A, Jovanovic Z, Sternic N
Faculty of Medicine, University of Belgrade, Serbia Department of Physiology, Faculty of Pharmacy, University of Belgrade, Serbia.
Faculty of Medicine, University of Belgrade, Serbia Institute of Mental Health, Serbia.
Cephalalgia. 2016 May;36(6):561-7. doi: 10.1177/0333102415607191. Epub 2015 Sep 29.
The aim of this study was to evaluate the prevalence and clinical impact of interictal microembolic signals (MES) in patients suffering from migraine with higher cortical dysfunction (HCD), such as language and memory impairment, during an aura.
This study was carried out on 34 migraineurs with language and memory impairment during aura (HCD group), 31 migraineurs with only visual or visual and somatosensory symptoms during aura (Control group I), and 34 healthy controls (Control group II). We used a Doppler instrument to detect microemboli. Demographic data, disease features and the detection of MES between these groups, as well as the predictors of HCD during the aura, were analyzed.
The duration of aura was longer and the frequency of aura was higher among patients with language and memory impairment during aura compared to Control group I. MES was detected in 29.4% patients from the HCD group, which was significantly higher compared to 3.2% in Control group I and 5.9% in Control group II. Regarding the absence or presence of MES, demographic and aura features were not different in the HCD subgroups. A longer duration of aura, the presence of somatosensory symptoms during the aura and the presence of interictal MES were independent predictors of HCD during the aura.
The present findings indicate that HCD and MES are related in patients with migraine with aura. Further research is needed to better understand the exact pathophysiological mechanism.
本研究旨在评估偏头痛伴高级皮质功能障碍（HCD）患者在先兆期出现发作间期微栓塞信号（MES）的患病率及其临床影响，这些患者在先兆期存在如语言和记忆障碍等高级皮质功能障碍。
本研究纳入了34例在先兆期有语言和记忆障碍的偏头痛患者（HCD组）、31例仅在先兆期有视觉或视觉及躯体感觉症状的偏头痛患者（对照组I）以及34名健康对照者（对照组II）。我们使用多普勒仪器检测微栓子。分析了这些组之间的人口统计学数据、疾病特征以及MES的检测情况，还有先兆期HCD的预测因素。
与对照组I相比，先兆期有语言和记忆障碍的患者，其先兆期持续时间更长，先兆发作频率更高。HCD组中29.4%的患者检测到MES，这显著高于对照组I的3.2%和对照组II的5.9%。就MES的有无而言，HCD亚组的人口统计学和先兆特征并无差异。先兆期持续时间更长、先兆期存在躯体感觉症状以及存在发作间期MES是先兆期HCD的独立预测因素。
目前的研究结果表明，有先兆偏头痛患者的HCD与MES有关。需要进一步研究以更好地理解确切的病理生理机制。
