Skoner D P, Fireman P, Davis H W, Wall R, Caliguiri L A
Division of Allergy/Immunology, University of Pittsburgh.
Arch Dis Child. 1989 Aug;64(8):1112-7. doi: 10.1136/adc.64.8.1112.
Plasma concentrations of a stable prostaglandin F2 alpha metabolite were measured by radioimmunoassay during and after recovery from acute airway obstruction in 15 infants. Mean (SEM) metabolite concentrations (ng/l) in plasma obtained both before (1033 (418)) and after (1470 (413)) initial treatment for airway obstruction were significantly higher than those obtained from the same subjects after resolution of the obstruction--25.5 (6.6)--and those obtained from two comparison groups. Infants positive for respiratory syncytial virus (mean 1122 (227)) had significantly higher concentrations than those who were negative (207.6 (46)). Additionally, seven subjects with a history of recurrent wheezing after resolution of airway obstruction had a significantly higher mean level (3500 (1400)) during attacks of airway obstruction than those without (600 (100)). These data suggest that prostaglandin F2 alpha mediates respiratory inflammation in airway obstruction and that trials of specific anti-inflammatory agents for the treatment of airway obstruction may be warranted.
采用放射免疫分析法测定了15例婴儿急性气道梗阻发作期间及恢复后血浆中稳定的前列腺素F2α代谢产物的浓度。气道梗阻初始治疗前（1033（418））和治疗后（1470（413））采集的血浆中代谢产物浓度（ng/l）的均值（标准误）显著高于梗阻解除后同一受试者的浓度（25.5（6.6））以及两个对照组的浓度。呼吸道合胞病毒检测呈阳性的婴儿（均值1122（227））的浓度显著高于阴性婴儿（207.6（46））。此外，7例气道梗阻解除后有反复喘息病史的受试者在气道梗阻发作期间的平均水平（3500（1400））显著高于无反复喘息病史的受试者（600（100））。这些数据表明，前列腺素F2α介导气道梗阻中的呼吸道炎症，可能有必要对治疗气道梗阻的特异性抗炎药物进行试验。
