Skoner D P, Fireman P, Caliguiri L, Davis H
Division of Allergy/Immunology, Children's Hospital of Pittsburgh, PA 15213.
Am Rev Respir Dis. 1990 Aug;142(2):359-64. doi: 10.1164/ajrccm/142.2.359.
Acute bronchiolitis (AB) is a common lung disease in infants manifested clinically by dyspnea and wheezing. The purpose of this study was to measure simultaneous plasma levels of histamine and a stable prostaglandin F2 alpha metabolite [13,14-dihydro-15-keto-PGF2 alpha (PG metabolite)], by radioenzymatic and radioimmunoassays, respectively, during and after recovery from AB. Blood was obtained from 15 infants during AB and from 14 and 9 of these infants when re-evaluated 6 and 18 months later, respectively. Mean (+/- 1 SEM) pre- and posttherapy (inhaled isoetharine) histamine levels (pg/ml), 1,923 +/- 980 and 1,035 +/- 250 during AB, respectively, were markedly higher than those of the same nonwheezing subjects at 18 months, 360 +/- 125, but unexpectedly lower than those at 6 months, 9,210 +/- 5,242. Of the 14 infants evaluated at 6 months, 7 had elevated histamine levels along with histories of recurrent wheezing after AB. Similarly, pre- and posttherapy PG metabolite levels (pg/ml), 1,033 +/- 419 and 1,613 +/- 527, respectively, were significantly higher than those of the same children when asymptomatic at 6 (27 +/- 7) and 18 months (68 +/- 25). Pre- and posttherapy levels of histamine and PG metabolite were higher than those of normal and sick, nonwheezing infants. These data indicate that histamine and PG metabolite are detectable in plasma during AB and suggest a role for histamine and PGF2 alpha in the pathogenesis of airways inflammation in AB.
急性细支气管炎（AB）是婴幼儿常见的肺部疾病，临床症状表现为呼吸急促和喘息。本研究的目的是通过放射酶法和放射免疫分析法分别测定AB期间及恢复后血浆中组胺和稳定的前列腺素F2α代谢物[13,14-二氢-15-酮-前列腺素F2α（PG代谢物）]的水平。分别从15名患AB的婴儿身上采集血液，在6个月和18个月后重新评估时，分别从其中14名和9名婴儿身上采集血液。AB期间治疗前和治疗后（吸入异丙喘宁）组胺水平的平均值（±1标准误，pg/ml）分别为1,923±980和1,035±250，显著高于同组非喘息受试者18个月时的水平（360±125），但出乎意料地低于6个月时的水平（9,210±5,242）。在6个月时接受评估的14名婴儿中，有7名组胺水平升高，且AB后有反复喘息病史。同样，治疗前和治疗后PG代谢物水平（pg/ml）分别为1,033±419和1,613±527，显著高于同组儿童在6个月（27±7）和18个月（68±25）无症状时的水平。组胺和PG代谢物的治疗前和治疗后水平均高于正常和患病的非喘息婴儿。这些数据表明，在AB期间血浆中可检测到组胺和PG代谢物，并提示组胺和前列腺素F2α在AB气道炎症发病机制中起作用。
