Yano Shozo, Nabika Toru, Nagai Atsushi, Hamano Tsuyoshi, Yamasaki Masayuki, Isomura Minoru, Shiwaku Kuninori, Yamaguchi Shuhei, Yamaguchi Toru, Sugimoto Toshitsugu
Department of Laboratory Medicine, Shimane University Faculty of Medicine, Shimane, Japan. Email:
Shimane community-based health research and education (CoHRE), Shimane, Japan.
Asia Pac J Clin Nutr. 2015;24(3):489-95. doi: 10.6133/apjcn.2015.24.4.02.
Undercarboxylated osteocalcin (ucOC) produced from the bone was recently found to play a regulatory role in the insulin and adiponectin secretion. We performed a cross-sectional study to investigate the relationship between ucOC and diabetes mellitus (DM).
We included 1,870 subjects aged over 50 from participants of a health examination. According to the current medication and past history, 605 subjects had hypertension (HT), 316 had dyslipidemia (DL), and 182 had type 2 DM. Fasting blood samples were collected to measure concentrations of ucOC and the bone turnover marker, tartrate-resistant acid phosphatase 5b (TRACP5b) by ELISA.
The serum ucOC level was significantly lower in DM(+) than DM(-) in both men and women. In a logistic regression analysis, a low level of ucOC was significantly associated with the presence of DM in both men and women after adjusting for age, BMI, serum creatinine, triglyceride, and TRACP5b. Multiple regression analysis showed a negative association of ucOC with HbA1c and fasting plasma glucose, and a positive association with the insulin level. In contrast, no association was found between TRACP5b and the indices above, suggesting that the effect of ucOC on the insulin secretion and the glycemic status was independent of bone turnover.
The present cross-sectional study showed a significant association between ucOC and glucose metabolism after correction with bone turnover in a community-dwelling population both in men and women, indicating that ucOC may play an important role in the pathogenesis of DM through the pathways independent of bone metabolism.
最近发现由骨骼产生的羧化不足骨钙素（ucOC）在胰岛素和脂联素分泌中发挥调节作用。我们进行了一项横断面研究，以调查ucOC与糖尿病（DM）之间的关系。
我们纳入了1870名年龄超过50岁的健康体检参与者。根据当前用药情况和既往病史，605名受试者患有高血压（HT），316名患有血脂异常（DL），182名患有2型糖尿病。采集空腹血样，通过酶联免疫吸附测定法（ELISA）测量ucOC和骨转换标志物抗酒石酸酸性磷酸酶5b（TRACP5b）的浓度。
无论男性还是女性，DM（+）组的血清ucOC水平均显著低于DM（-）组。在逻辑回归分析中，在校正年龄、体重指数、血清肌酐、甘油三酯和TRACP5b后，低水平的ucOC与男性和女性DM的存在均显著相关。多元回归分析显示，ucOC与糖化血红蛋白（HbA1c）和空腹血糖呈负相关，与胰岛素水平呈正相关。相比之下，未发现TRACP5b与上述指标之间存在关联，这表明ucOC对胰岛素分泌和血糖状态的影响独立于骨转换。
本横断面研究表明，在社区居住人群中，校正骨转换后，ucOC与葡萄糖代谢之间存在显著关联，无论男性还是女性，这表明ucOC可能通过独立于骨代谢的途径在DM发病机制中发挥重要作用。
