Liu Zixu, Mao Yuchen, Yang Kangping, Wang Shukai, Zou Fang
Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
The First Clinical Medicine School, Nanchang University, Nanchang, China.
Front Endocrinol (Lausanne). 2025 Jan 13;15:1475214. doi: 10.3389/fendo.2024.1475214. eCollection 2024.
Osteocalcin has attracted attention for its potential role in diabetes management. However, there has been no bibliometric assessment of scientific progress in this field.
We analysed 1680 articles retrieved from the Web of Science Core Collection (WoSCC) between 1 January 1986 and 10 May 2024 using various online tools.
These papers accumulated 42,714 citations,with an average of 25.43 citations per paper. Publication output increased sharply from 1991 onwards. The United States and China are at the forefront of this research area.
The keywords were grouped into four clusters: 'Differential and functional osteocalcin genes', 'Differential expression of osteocalcin genes in relation to diabetes mellitus', 'Role of osteocalcin in the assessment of osteoporosis and diabetes mellitus', and 'Indirect involvement of osteocalcin in metabolic processes'. Analysis using the VoS viewer suggests a shift in research focus towards the correlation between osteocalcin levels and diabetic complications, the clinical efficacy of therapeutic agents or vitamins in the treatment of osteoporosis in diabetic patients, and the mechanisms by which osteocalcin modulates insulin action. The proposed focus areas are "osteocalcin genes", "insulin regulation and osteoporosis ", "different populations", "diabetes-related complications" and "type 2 diabetes mellitus","effect of osteocalcin expression on insulin sensitivity as well as secretion","osteocalcin expression in different populations of diabetic patients and treatment-related studies".
骨钙素因其在糖尿病管理中的潜在作用而备受关注。然而，该领域尚未有科学进展的文献计量学评估。
我们使用各种在线工具分析了1986年1月1日至2024年5月10日期间从科学引文索引核心合集（WoSCC）检索到的1680篇文章。
这些论文累计被引用42714次，平均每篇论文被引用25.43次。自1991年起，论文发表量急剧增加。美国和中国在这一研究领域处于前沿地位。
关键词被分为四个聚类：“骨钙素基因的差异与功能”、“骨钙素基因与糖尿病的差异表达”、“骨钙素在骨质疏松症和糖尿病评估中的作用”以及“骨钙素在代谢过程中的间接参与”。使用VoS viewer进行的分析表明，研究重点已转向骨钙素水平与糖尿病并发症之间的相关性、治疗药物或维生素在糖尿病患者骨质疏松症治疗中的临床疗效，以及骨钙素调节胰岛素作用的机制。建议的重点领域包括“骨钙素基因”、“胰岛素调节与骨质疏松症”、“不同人群”、“糖尿病相关并发症”和“2型糖尿病”、“骨钙素表达对胰岛素敏感性及分泌的影响”、“糖尿病患者不同人群中的骨钙素表达及治疗相关研究”。
