靶向多梳系统以调控基因表达：复杂故事的修正
Targeting Polycomb systems to regulate gene expression: modifications to a complex story.
作者信息
Blackledge Neil P, Rose Nathan R, Klose Robert J
机构信息
Department of Biochemistry, South Parks Road, University of Oxford, OX1 3QU.
出版信息
Nat Rev Mol Cell Biol. 2015 Nov;16(11):643-649. doi: 10.1038/nrm4067. Epub 2015 Sep 30.
Abstract
Polycomb group proteins are transcriptional repressors that are essential for normal gene regulation during development. Recent studies suggest that Polycomb repressive complexes (PRCs) recognize and are recruited to their genomic target sites through a range of different mechanisms, which involve transcription factors, CpG island elements and non-coding RNAs. Together with the realization that the interplay between PRC1 and PRC2 is more intricate than was previously appreciated, this has increased our understanding of the vertebrate Polycomb system at the molecular level.
摘要
多梳蛋白家族是转录抑制因子，在发育过程中对正常基因调控至关重要。最近的研究表明，多梳抑制复合物（PRC）通过一系列不同机制识别并被招募到其基因组靶位点，这些机制涉及转录因子、CpG岛元件和非编码RNA。随着人们认识到PRC1和PRC2之间的相互作用比之前认为的更为复杂，这增加了我们在分子水平上对脊椎动物多梳系统的理解。
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