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尿液标记物检测:一种替代有监督尿液收集的兴奋剂控制方法。

The Urine Marker Test: An Alternative Approach to Supervised Urine Collection for Doping Control.

机构信息

Department of Nutrition, Exercise and Sports, University of Copenhagen, Nørre Allé 51, 2200, Copenhagen N, Denmark.

RUMA GmbH, Aachener Straße 338, 50933, Cologne, Germany.

出版信息

Sports Med. 2016 Jan;46(1):15-22. doi: 10.1007/s40279-015-0388-6.

DOI:10.1007/s40279-015-0388-6
PMID:26420237
Abstract

BACKGROUND

Urine sample collection for doping control tests is a key component of the World Anti-Doping Agency's fight against doping in sport. However, a substantial number of athletes experience difficulty when having to urinate under supervision. Furthermore, it cannot always be ensured that athletes are actually delivering their own urine. A method that can be used to alleviate the negative impact of a supervised urination procedure and which can also identify urine as coming from a specific athlete is the urine marker test. Monodisperse low molecular weight polyethylene glycols (PEGs) are given orally prior to urination. Urine samples can be traced to the donor by analysis of the PEGs previously given.

OBJECTIVE

The objective of this study was to investigate the use of the urine marker during urine doping control testing.

METHODS

Two studies investigated athletes' acceptance of this new method via two questionnaires (n = 253). Furthermore, a third study (n = 91) investigated whether ingestion of the marker can identify the urine as coming from a specific person and whether the marker interferes with the detection of prohibited substances.

RESULTS AND CONCLUSIONS

The results indicate that this new method finds wide acceptance both from athletes who have only heard about the procedure and those who have actually tested the new method. Furthermore, the marker, which can identify urine as coming from a specific person, does not interfere with the detection of prohibited substances.

摘要

背景

尿样采集是世界反兴奋剂机构打击运动兴奋剂的关键组成部分。然而,相当数量的运动员在监督下排尿时会遇到困难。此外,也不能总是确保运动员实际提供自己的尿液。一种可以减轻监督排尿程序负面影响并可以识别尿液来自特定运动员的方法是尿液标记物测试。在排尿前口服单分散低分子量聚乙二醇(PEG)。通过分析先前给予的 PEG,可以追踪尿液样本的来源。

目的

本研究旨在调查尿液标记物在尿液兴奋剂检测中的使用。

方法

两项研究通过两份问卷(n=253)调查了运动员对这种新方法的接受程度。此外,第三项研究(n=91)调查了标记物的摄入是否可以识别尿液来自特定的人,以及标记物是否会干扰违禁物质的检测。

结果与结论

结果表明,这种新方法在仅听说过该程序的运动员和实际测试新方法的运动员中都得到了广泛的认可。此外,该标记物可以识别尿液来自特定的人,并且不会干扰违禁物质的检测。

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Paruresis (shy bladder syndrome): a cognitive-behavioral treatment approach.尿羞症(害羞膀胱综合征):一种认知行为治疗方法。
Soc Work Health Care. 2010;49(5):494-507. doi: 10.1080/00981381003684898.
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Self-reported attitudes of elite athletes towards doping: differences between type of sport.精英运动员对使用兴奋剂的自我报告态度:不同运动项目之间的差异。
Int J Sports Med. 2006 Oct;27(10):842-6. doi: 10.1055/s-2005-872969. Epub 2006 Feb 1.
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Urine labeling with orally applied marker substances in drug substitution therapy.药物替代治疗中口服标记物质对尿液的标记
Clin Chem Lab Med. 2004;42(6):621-6. doi: 10.1515/CCLM.2004.107.
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Clinical use of polyethylene glycols as marker substances and determination in urine by liquid chromatography.聚乙二醇作为标记物质的临床应用及尿液中液相色谱法测定
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Drug testing at the Sydney Olympics.悉尼奥运会的药物检测。
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