Zhang Chuan-Tao, He Ke-Cheng, Pan Fei, Li Yuan, Wu Jiang
Chuan-Tao Zhang, Teaching Hospital of Chengdu University of Traditional Chinese Medicine and Sichuan Province Traditional Chinese Medicine Hospital, Chengdu 610041, Sichuan Province, China.
World J Gastroenterol. 2015 Sep 28;21(36):10453-60. doi: 10.3748/wjg.v21.i36.10453.
To assess the correlation between decreased Muc5AC expression and patients' survival and clinicopathological characteristics by conducting a meta-analysis.
Literature searches were performed in PubMed and EMBASE, and 11 studies met our criteria. Summary hazard ratios or odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the effect. For the pooled analysis of the correlation between decreased Muc5AC expression and clinicopathological characteristics (tumour invasion depth, lymph node metastasis, tumour-node-metastasis stage, tumour size, venous invasion and lymphatic invasion), ORs and their variance were combined to estimate the effect.
Eleven retrospective cohort studies comprising 2135 patients were included to assess the association between Muc5AC expression and overall survival and/or clinicopathological characteristics. Decreased Muc5AC expression was significantly correlated with poor overall survival of gastric cancer patients (pooled HR = 1.35, 95%CI: 1.08-1.7). Moreover, decreased Muc5AC expression was also significantly associated with tumour invasion depth (pooled OR = 2.12, 95%CI: 1.56-2.87) and lymph node metastasis (pooled OR = 1.56, 95%CI: 1.00-2.44) in gastric cancer.
Decreased Muc5AC expression might be a poor prognostic predictor for gastric cancer.
通过进行一项荟萃分析，评估黏蛋白5AC（Muc5AC）表达降低与患者生存率及临床病理特征之间的相关性。
在PubMed和EMBASE中进行文献检索，11项研究符合我们的标准。计算汇总风险比或比值比（OR）及其95%置信区间（CI）以估计效应。对于Muc5AC表达降低与临床病理特征（肿瘤浸润深度、淋巴结转移、肿瘤-淋巴结-转移分期、肿瘤大小、静脉侵犯和淋巴侵犯）之间相关性的汇总分析，合并OR及其方差以估计效应。
纳入11项回顾性队列研究，共2135例患者，以评估Muc5AC表达与总生存期和/或临床病理特征之间的关联。Muc5AC表达降低与胃癌患者较差的总生存期显著相关（汇总HR = 1.35，95%CI：1.08 - 1.7）。此外，Muc5AC表达降低在胃癌中也与肿瘤浸润深度（汇总OR = 2.12，95%CI：1.56 - 2.87）和淋巴结转移（汇总OR = 1.56，95%CI：1.00 - 2.44）显著相关。
Muc5AC表达降低可能是胃癌预后不良的预测指标。
