一种用于冷冻疗法和控制皮肤血流的现场热电冷却装置。
An On-Site Thermoelectric Cooling Device for Cryotherapy and Control of Skin Blood Flow.
作者信息
Mejia Natalia, Dedow Karl, Nguy Lindsey, Sullivan Patrick, Khoshnevis Sepideh, Diller Kenneth R
机构信息
Department of Biomedical Engineering, The University of Texas at Austin, 107 West Dean Keeton Street, Austin, TX 78712-1081 e-mail:
Fellow ASME Department of Biomedical Engineering, The University of Texas at Austin, 107 West Dean Keeton Street, Austin, TX 78712-1081 e-mail:
出版信息
J Med Device. 2015 Dec;9(4):0445021-445026. doi: 10.1115/1.4029508. Epub 2015 Aug 6.
Cryotherapy involves the surface application of low temperatures to enhance the healing of soft tissue injuries. Typical devices embody a remote source of chilled water that is pumped through a circulation bladder placed on the treatment site. In contrast, the present device uses thermoelectric refrigeration modules to bring the cooling source directly to the tissue to be treated, thereby achieving significant improvements in control of therapeutic temperature while having a reduced size and weight. A prototype system was applied to test an oscillating cooling and heating protocol for efficacy in regulating skin blood perfusion in the treatment area. Data on 12 human subjects indicate that thermoelectric coolers (TECs) delivered significant and sustainable changes in perfusion for both heating (increase by (±SE) 173.0 ± 66.0%, P < 0.005) and cooling (decrease by (±SE) 57.7 ± 4.2%, P < 0.0005), thus supporting the feasibility of a TEC-based device for cryotherapy with local temperature regulation.
冷冻疗法是指通过在体表施加低温来促进软组织损伤的愈合。典型的设备包含一个远程冷水源，冷水通过放置在治疗部位的循环气囊进行泵送。相比之下，本设备使用热电制冷模块将冷却源直接带到待治疗的组织，从而在控制治疗温度方面取得显著改进，同时减小了尺寸和重量。应用了一个原型系统来测试一种振荡冷却和加热方案，以评估其在调节治疗区域皮肤血液灌注方面的效果。12名人体受试者的数据表明，热电冷却器（TEC）在加热（增加（±标准误）173.0±66.0%，P<0.005）和冷却（减少（±标准误）57.7±4.2%，P<0.0005）时都能使灌注产生显著且可持续的变化，从而支持了基于TEC的设备用于局部温度调节冷冻疗法的可行性。
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