Diller Kenneth R
Department of Biomedical Engineering, The University of Texas at Austin , 107 West Dean Keeton Street , BME 4.202A , Austin, TX 78712-1084 e-mail:
J Heat Transfer. 2015 Oct;137(10):1030011-10300112. doi: 10.1115/1.4030424.
Our bodies depend on an exquisitely sensitive and refined temperature control system to maintain a state of health and homeostasis. The exceptionally broad range of physical activities that humans engage in and the diverse array of environmental conditions we face require remarkable strategies and mechanisms for regulating internal and external heat transfer processes. On the occasions for which the body suffers trauma, therapeutic temperature modulation is often the approach of choice for reversing injury and inflammation and launching a cascade of healing. The focus of human thermoregulation is maintenance of the body core temperature within a tight range of values, even as internal rates of energy generation may vary over an order of magnitude, environmental convection, and radiation heat loads may undergo large changes in the absence of any significant personal control, surface insulation may be added or removed, all occurring while the body's internal thermostat follows a diurnal circadian cycle that may be altered by illness and anesthetic agents. An advanced level of understanding of the complex physiological function and control of the human body may be combined with skill in heat transfer analysis and design to develop life-saving and injury-healing medical devices. This paper will describe some of the challenges and conquests the author has experienced related to the practice of heat transfer for maintenance of health and enhancement of healing processes.
我们的身体依赖于一个极其敏感和精细的温度控制系统来维持健康和体内平衡状态。人类所从事的体育活动范围极为广泛,我们所面临的环境条件多种多样,这就需要卓越的策略和机制来调节内部和外部的热传递过程。当身体遭受创伤时,治疗性温度调节往往是逆转损伤和炎症以及启动一系列愈合过程的首选方法。人体体温调节的重点是将身体核心温度维持在一个狭窄的数值范围内,即便内部能量产生速率可能相差一个数量级,环境对流和辐射热负荷在没有任何显著个人控制的情况下可能会发生很大变化,体表隔热层可能会增减,而这一切都发生在人体内部恒温器遵循昼夜节律周期的同时,该周期可能会因疾病和麻醉剂而改变。对人体复杂生理功能和控制的深入理解可以与传热分析和设计技能相结合,以开发挽救生命和促进伤口愈合的医疗设备。本文将描述作者在传热实践中所经历的一些与维持健康和促进愈合过程相关的挑战与成就。