Henriksen Roger Ekeberg, Thuen Frode
Centre for Evidence-Based Practice, Bergen University College, Bergen, Norway.
PLoS One. 2015 Sep 30;10(9):e0137304. doi: 10.1371/journal.pone.0137304. eCollection 2015.
The aim of this study was to explore the degree to which couples' relationship dissatisfaction and stressful life events during pregnancy predict the risk of infectious disease in the offspring during their first year of life.
Data were obtained from the Norwegian Mother and Child Cohort Study, conducted by the Norwegian Institute of Public Health. Pregnant women completed questionnaires in week 30 of pregnancy concerning the couples' relationship satisfaction and stressful life events. In follow-up questionnaires, the women reported whether their children (n = 74,801) had been subject to various categories of infectious disease: the common cold, throat infection, bronchitis, RS virus, pneumonia, pseudocroup, gastric flu, ear infection, conjunctivitis and urinary tract infection. Reports from two age groups of infants were used. Associations between the predictor and outcome variables were assessed via logistic regression and linear regression analyses.
Separate logistic regression analyses for each disease and age group showed that prenatal relationship dissatisfaction and stressful life events were significantly associated with all reported categories of infectious disease. After controlling for socioeconomic factors, social support, smoking, breastfeeding, maternal depression, the sex of the offspring, and use of child care, 29 out of 32 tested associations were statistically significant. Finally, multivariate linear regression analyses showed that prenatal relationship dissatisfaction and stressful life events were significantly associated with the frequency, as well as the variety, of infectious disease in the offspring.
本研究旨在探讨孕期夫妻关系不满意和生活应激事件对其子女出生后第一年感染性疾病风险的预测程度。
数据来自挪威公共卫生研究所开展的挪威母婴队列研究。孕妇在孕期第30周填写问卷，内容涉及夫妻关系满意度和生活应激事件。在随访问卷中，这些女性报告其子女（n = 74,801）是否患过各类感染性疾病：普通感冒、咽喉感染、支气管炎、呼吸道合胞病毒、肺炎、假膜性喉炎、胃肠型感冒、耳部感染、结膜炎和尿路感染。采用了两个年龄组婴儿的报告。通过逻辑回归和线性回归分析评估预测变量和结果变量之间的关联。
针对每种疾病和年龄组的单独逻辑回归分析表明，产前关系不满意和生活应激事件与所有报告的感染性疾病类别均显著相关。在控制了社会经济因素、社会支持、吸烟、母乳喂养、母亲抑郁、子女性别和儿童保育使用情况后，32项测试关联中的29项具有统计学意义。最后，多元线性回归分析表明，产前关系不满意和生活应激事件与子女感染性疾病的频率和种类均显著相关。
