Argamany Jacqueline R, Reveles Kelly R, Duhon Bryson
College of Pharmacy, The University of Texas at Austin, Austin, TX, USA; Pharmacotherapy Education and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
College of Pharmacy, The University of Texas at Austin, Austin, TX, USA; Pharmacotherapy Education and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; Pharmacy Department, University Health System, San Antonio, TX, USA.
Am J Emerg Med. 2016 Apr;34(4):765.e1-2. doi: 10.1016/j.ajem.2015.08.051. Epub 2015 Sep 7.
Synthetic cannabinoid usage has increased in the past decade. Concurrently, emergency management of associated adverse effects due to synthetic cannabinoid usage has also risen. Reported toxicities include psychosis, seizures, cardiotoxicity, acute kidney injury, and death. While cannabis was first described as a cause of acute hyperemesis in 2004, a more recent case series also describes the association between cannabinoid hyperemesis and risk of acute renal failure. Synthetic cannabinoids have also been reported to cause acute hyperemesis and acute renal failure; however, the risk of rhabdomyolysis-induced renal failure has yet to be elucidated. In this article, we report the first known case of synthetic cannabinoid hyperemesis leading to rhabdomyolysis and acute renal failure.
在过去十年中，合成大麻素的使用有所增加。与此同时，因使用合成大麻素而进行的相关不良反应的应急处理也有所增加。报告的毒性包括精神病、癫痫发作、心脏毒性、急性肾损伤和死亡。虽然大麻在2004年首次被描述为急性呕吐的一个原因，但最近的一个病例系列也描述了大麻素呕吐与急性肾衰竭风险之间的关联。也有报道称合成大麻素会导致急性呕吐和急性肾衰竭；然而，横纹肌溶解引起的肾衰竭风险尚未阐明。在本文中，我们报告了首例已知的因合成大麻素呕吐导致横纹肌溶解和急性肾衰竭的病例。
