代谢综合征及其与左束支传导阻滞患者左心室功能障碍的关联。
Metabolic syndrome and its association with left ventricular dysfunction in patients with left bundle branch block.
作者信息
Gharipour Mojgan, Hashemi Jazi Mohammad, Nilforoush Peyman, Batvandi Azadeh, Mohammadi Robabeh, Najafi Roya
机构信息
Molecular epidemiology, Metabolic Syndrome Department, Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Acta Biomed. 2015 Sep 14;86(2):157-61.
BACKGROUND
The present study and for the first time hypothesizes that the patients with left bundle branch block (LBBB) suffer considerably from metabolic syndrome (MetS) and this metabolic phenomenon can be associated with cardiac dysfunction status such as ventricular dilation and reduced left ventricular ejection fraction (LVEF) in these patients.
METHODS
A retrospective study was conducted on 220 consecutive patients with diagnosed LBBB. MetS status was diagnosed using the Adult Treatment Panel III of the National Cholesterol Education Program criteria. Systolic function state was assessed using two-dimensional echocardiography.
RESULTS
The overall prevalence of MetS among studied LBBB patients was 16.8%. Regarding left ventricular functional status in the two groups, the mean LVEF in the groups with and without MetS was 37.03 ± 9.09% and 43.43 ± 15.62% with a significant difference (p = 0.017). However, left ventricular dilation was similarly detected in both groups with and without MetS (21.6% versus 30.6%, p = 0.273). Multivariable linear regression model showed subjects with MetS had lower LVEF in the presence of confounders (Beta = 6.915, p = 0.039).
CONCLUSION
A notable number of LBBB patients suffered from MetS and this metabolic phenomenon is significantly associated with lowering left ventricular function in LBBB patients.
背景
本研究首次提出假设，即左束支传导阻滞（LBBB）患者患有相当严重的代谢综合征（MetS），且这种代谢现象可能与这些患者的心脏功能障碍状态有关，如心室扩张和左心室射血分数（LVEF）降低。
方法
对220例连续诊断为LBBB的患者进行回顾性研究。采用美国国家胆固醇教育计划成人治疗小组第三次报告的标准诊断MetS状态。使用二维超声心动图评估收缩功能状态。
结果
在研究的LBBB患者中，MetS的总体患病率为16.8%。关于两组的左心室功能状态，有MetS组和无MetS组的平均LVEF分别为37.03±9.09%和43.43±15.62%，差异有统计学意义（p = 0.017）。然而，在有MetS组和无MetS组中均同样检测到左心室扩张（分别为21.6%和30.6%，p = 0.273）。多变量线性回归模型显示，在存在混杂因素的情况下，患有MetS的受试者LVEF较低（β = 6.915，p = 0.039）。
结论
相当数量的LBBB患者患有MetS，这种代谢现象与LBBB患者左心室功能降低显著相关。
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