Turk J Med Sci. 2015;45(4):745-50.
BACKGROUND/AIM: Congenital hypothyroidism (CH) is divided into two groups as 'permanent' and 'transient' We aimed to determine the rate of transient and permanent congenital hypothyroidism of the newborns referred to our clinic.
Of the newborns who were referred to our clinic from the neonatal screening program, those who were diagnosed with CH and started treatment were included in the study. The treatments of the patients whose required daily treatment dose was reduced to under 1 µg/kg were terminated and those who were followed monthly and whose fT4 and thyroid-stimulating hormone (TSH) levels were normal at least 3 times without treatment were considered to have transient hypothyroidism.
Of the 256 newborns referred to our clinic from the neonatal screening program, 114 (44.5%) were diagnosed with CH. Of the CH patients, 70% (n = 58) were evaluated to have permanent and 30% (n = 25) transient hypothyroidism. Neonatal and serum TSH levels and treatment doses were found to be significantly lower in the transient hypothyroidism patients.
Initial measurements of the serum TSH level and the required doses of L-thyroxine therapy for maintaining normal thyroid hormone levels, growth, and development may have a predictive role for differentiating permanent forms of CH from transient forms.
背景/目的：先天性甲状腺功能减退症（CH）分为“永久性”和“暂时性”两类。我们旨在确定就诊新生儿暂时性和永久性先天性甲状腺功能减退症的发生率。
从新生儿筛查计划转介至我们诊所的新生儿中，将被诊断为 CH 并开始治疗的患者纳入研究。那些每日所需治疗剂量减少至 1μg/kg 以下的患者停止治疗，并且每月随访且至少 3 次无需治疗时游离甲状腺素（fT4）和促甲状腺激素（TSH）水平正常的患者被认为患有暂时性甲状腺功能减退症。
从新生儿筛查计划转介至我们诊所的 256 名新生儿中，有 114 名（44.5%）被诊断为 CH。在 CH 患者中，70%（n=58）被评估为永久性，30%（n=25）为暂时性甲状腺功能减退症。暂时性甲状腺功能减退症患者的新生儿和血清 TSH 水平以及治疗剂量明显较低。
初始测量血清 TSH 水平和维持正常甲状腺激素水平、生长和发育所需的 L-甲状腺素治疗剂量可能对区分永久性和暂时性 CH 有预测作用。
