Turk J Med Sci. 2015;45(4):959-63. doi: 10.3906/sag-1311-79.
BACKGROUND/AIM: We aimed to compare the effectiveness of esmolol 1 mg/kg and lidocaine 1 mg/kg for injection pain and for the prevention of rocuronium-induced withdrawal response.
We enrolled a total of 81 patients in the study. Patients were randomly assigned to receive either 10 mL of 0.9% NaCl (Group P), esmolol 1 mg/kg (Group E), or lidocaine 1.0 mg/kg (Group L). A subparalyzing dose of rocuronium 0.05 mg/ kg was administered to all patients and its effects were recorded. Anesthesia was induced with intravenous propofol and intravenous rocuronium 0.5 mg/kg in all groups. The withdrawal movements of the patient groups were subsequently graded.
There was a statistically significant difference in overall incidence of pain in group E and L compared to the placebo group after administrating the subparalyzed dose (no pain response: Group E = 81.5%, Group L = 77.8%, Group P = 14.8%) (P < 0.001). After intravenous administration of an intubating dose of rocuronium, the esmolol group had a significantly lower incidence of withdrawal movement than the other groups (no response: Group E = 81.5%, Group L = 63%, Group P = 22.2%) (P < 0.001).
We found that esmolol significantly attenuates rocuronium-induced withdrawal movement and also reduces pain when used at subparalyzing doses.
背景/目的：我们旨在比较 1mg/kg 艾司洛尔和 1mg/kg 利多卡因注射痛的疗效，以及预防罗库溴铵诱发的停药反应。
我们共纳入 81 例患者进行本研究。患者随机分为三组，分别接受 10ml0.9%生理盐水（P 组）、1mg/kg 艾司洛尔（E 组）或 1mg/kg 利多卡因（L 组）。所有患者均给予亚麻痹剂量罗库溴铵 0.05mg/kg，并记录其效果。所有组均静脉注射丙泊酚和罗库溴铵 0.5mg/kg 诱导麻醉。随后对患者组的停药动作进行分级。
与给予亚麻痹剂量后接受安慰剂的 P 组相比，E 组和 L 组的总疼痛发生率有统计学显著差异（无疼痛反应：E 组=81.5%，L 组=77.8%，P 组=14.8%）（P<0.001）。静脉给予插管剂量罗库溴铵后，艾司洛尔组停药动作的发生率明显低于其他组（无反应：E 组=81.5%，L 组=63%，P 组=22.2%）（P<0.001）。
我们发现艾司洛尔可显著减轻罗库溴铵诱发的停药动作，并且在使用亚麻痹剂量时也可减轻疼痛。
