Shahlaee Abtin, Pefkianaki Maria, Hsu Jason, Ho Allen C
Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, Pennsylvania.
Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, Pennsylvania.
Am J Ophthalmol. 2016 Jan;161:50-5.e1. doi: 10.1016/j.ajo.2015.09.026. Epub 2015 Sep 28.
To measure foveal avascular zone (FAZ) dimensions in healthy eyes using optical coherence tomography angiography (OCTA) and calculate interobserver variability.
Reliability analysis.
Thirty-four eyes of 17 healthy subjects underwent OCTA at the Retina Service of Wills Eye Hospital. Two masked graders performed measurements of FAZ dimensions including area, perimeter, and maximum horizontal and vertical diameters using ImageJ. Intraclass correlation coefficient (ICC) between graders was calculated.
Mean area (mm(2)), perimeter (mm), and maximum horizontal and vertical diameters (mm) were 0.27 ± 0.101, 2.21 ± 0.451, 0.59 ± 0.126, and 0.56 ± 0.118, respectively, at the superficial and 0.34 ± 0.116, 2.50 ± 0.462, 0.69 ± 0.123, and 0.63 ± 0.110 at the deep network. Interobserver agreement was high for all superficial FAZ measurements (ICC ≥0.90) but did not meet the lowest acceptable grader agreement for the deep vascular network (ICC <0.85). Fellow eyes had statistically similar values (P > .05).
Manual measurement of FAZ dimensions using OCTA is a noninvasive and reliable method for quantifying FAZ at the superficial vascular network. Assessing FAZ alterations in the deep vascular network may be subject to greater interobserver variability.
使用光学相干断层扫描血管造影（OCTA）测量健康眼睛的黄斑无血管区（FAZ）尺寸，并计算观察者间的变异性。
可靠性分析。
17名健康受试者的34只眼睛在威尔斯眼科医院视网膜科接受了OCTA检查。两名经过盲法分级的人员使用ImageJ测量FAZ尺寸，包括面积、周长以及最大水平和垂直直径。计算分级人员之间的组内相关系数（ICC）。
浅层网络的平均面积（mm²）、周长（mm）、最大水平和垂直直径（mm）分别为0.27±0.101、2.21±0.451、0.59±0.126和0.56±0.118，深层网络分别为0.34±0.116、2.50±0.462、0.69±0.123和0.63±0.110。所有浅层FAZ测量的观察者间一致性较高（ICC≥0.90），但深层血管网络未达到可接受的最低分级人员一致性（ICC<0.85）。对侧眼的值在统计学上相似（P>.05）。
使用OCTA手动测量FAZ尺寸是一种无创且可靠的方法，可用于量化浅层血管网络中的FAZ。评估深层血管网络中的FAZ改变可能存在更大的观察者间变异性。
