在健康受试者中使用扫频源光学相干断层扫描血管造影术测量黄斑无血管区面积的可重复性和重复性
Reproducibility and repeatability of foveal avascular zone area measurements using swept-source optical coherence tomography angiography in healthy subjects.
作者信息
Mastropasqua Rodolfo, Toto Lisa, Mattei Peter A, Di Nicola Marta, Zecca Isaia A L, Carpineto Paolo, Di Antonio Luca
机构信息
Ophthalmology Clinic, Moorfields Eye Hospital, London - UK.
Ophthalmology Clinic, Department of Medicine and Aging Sciences, High-Tech National Center in Ophthalmology, University "G. d'Annunzio" Chieti-Pescara, Chieti - Italy.
出版信息
Eur J Ophthalmol. 2017 May 11;27(3):336-341. doi: 10.5301/ejo.5000858. Epub 2016 Sep 9.
PURPOSE
To assess the reproducibility and repeatability of foveal avascular zone (FAZ) area measurements using swept-source optical coherence tomography angiography (SS-OCTA) in healthy subjects.
METHODS
Sixty-four eyes of 64 healthy volunteers were randomly subjected to FAZ area measurements using SS-OCTA by 2 examiners in 2 different sessions.
RESULTS
The FAZ areas measured by the first and second observer were 0.269 ± 0.092 mm2 and 0.270 ± 0.090 mm2, respectively. Within subjects, the coefficients of variations were 2.44% (95% confidence interval [CI] 1.95% to 2.93%) and 2.66% (95% CI 2.00% to 3.31%) for the first and second observers, respectively. The coefficient of repeatability average measurements of FAZ area were 0.021 mm2 and 0.024 mm2. The intraclass correlation coefficient values were 0.993 (95% CI 0.989 to 0.996) and 0.991 (95% CI 0.986 to 0.995). Interobserver and intraobserver concordance correlation coefficients ranged from 0.998 (95% CI 0.997 to 0.999) to 0.999 (95% CI 0.998 to 0.999) and from 0.989 (95% CI 0.982 to 0.993) to 0.987 (95% CI 0.979 to 0.992), respectively.
CONCLUSIONS
The FAZ area measurements by means of SS-OCTA showed high reproducibility and repeatability in healthy eyes.
目的
评估在健康受试者中使用扫频源光学相干断层扫描血管造影（SS-OCTA）测量黄斑无血管区（FAZ）面积的可重复性和重复性。
方法
64名健康志愿者的64只眼睛由2名检查者在2个不同时间段使用SS-OCTA随机进行FAZ面积测量。
结果
第一位观察者和第二位观察者测量的FAZ面积分别为0.269±0.092mm²和0.270±0.090mm²。在受试者内部，第一位和第二位观察者的变异系数分别为2.44%（95%置信区间[CI]1.95%至2.93%）和2.66%（95%CI 2.00%至3.31%）。FAZ面积平均测量的重复性系数分别为0.021mm²和0.024mm²。组内相关系数值分别为0.993（95%CI 0.989至0.996）和0.991（95%CI 0.986至0.995）。观察者间和观察者内一致性相关系数分别为0.998（95%CI 0.997至0.999）至0.999（95%CI 0.998至0.999）和0.989（95%CI 0.982至0.993）至0.987（95%CI 0.979至0.992）。
结论
通过SS-OCTA测量FAZ面积在健康眼睛中显示出高可重复性和重复性。
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