Mastropasqua Rodolfo, Toto Lisa, Mattei Peter A, Di Nicola Marta, Zecca Isaia A L, Carpineto Paolo, Di Antonio Luca
Ophthalmology Clinic, Moorfields Eye Hospital, London - UK.
Ophthalmology Clinic, Department of Medicine and Aging Sciences, High-Tech National Center in Ophthalmology, University "G. d'Annunzio" Chieti-Pescara, Chieti - Italy.
Eur J Ophthalmol. 2017 May 11;27(3):336-341. doi: 10.5301/ejo.5000858. Epub 2016 Sep 9.
To assess the reproducibility and repeatability of foveal avascular zone (FAZ) area measurements using swept-source optical coherence tomography angiography (SS-OCTA) in healthy subjects.
Sixty-four eyes of 64 healthy volunteers were randomly subjected to FAZ area measurements using SS-OCTA by 2 examiners in 2 different sessions.
The FAZ areas measured by the first and second observer were 0.269 ± 0.092 mm2 and 0.270 ± 0.090 mm2, respectively. Within subjects, the coefficients of variations were 2.44% (95% confidence interval [CI] 1.95% to 2.93%) and 2.66% (95% CI 2.00% to 3.31%) for the first and second observers, respectively. The coefficient of repeatability average measurements of FAZ area were 0.021 mm2 and 0.024 mm2. The intraclass correlation coefficient values were 0.993 (95% CI 0.989 to 0.996) and 0.991 (95% CI 0.986 to 0.995). Interobserver and intraobserver concordance correlation coefficients ranged from 0.998 (95% CI 0.997 to 0.999) to 0.999 (95% CI 0.998 to 0.999) and from 0.989 (95% CI 0.982 to 0.993) to 0.987 (95% CI 0.979 to 0.992), respectively.
The FAZ area measurements by means of SS-OCTA showed high reproducibility and repeatability in healthy eyes.
评估在健康受试者中使用扫频源光学相干断层扫描血管造影（SS-OCTA）测量黄斑无血管区（FAZ）面积的可重复性和重复性。
64名健康志愿者的64只眼睛由2名检查者在2个不同时间段使用SS-OCTA随机进行FAZ面积测量。
第一位观察者和第二位观察者测量的FAZ面积分别为0.269±0.092mm²和0.270±0.090mm²。在受试者内部，第一位和第二位观察者的变异系数分别为2.44%（95%置信区间[CI]1.95%至2.93%）和2.66%（95%CI 2.00%至3.31%）。FAZ面积平均测量的重复性系数分别为0.021mm²和0.024mm²。组内相关系数值分别为0.993（95%CI 0.989至0.996）和0.991（95%CI 0.986至0.995）。观察者间和观察者内一致性相关系数分别为0.998（95%CI 0.997至0.999）至0.999（95%CI 0.998至0.999）和0.989（95%CI 0.982至0.993）至0.987（95%CI 0.979至0.992）。
通过SS-OCTA测量FAZ面积在健康眼睛中显示出高可重复性和重复性。
