Célia Monteiro de Paula Regina, Andrade Feitosa Judith Pessoa, Beserra Paula Haroldo César
Organic and Inorganic Chemistry Department, Federal University of Ceará, CEP: 60455-760, Caixa Postal 6021 - R. Humberto Monte s/n, Campus do Pici, Brasil.
Curr Drug Targets. 2015;16(14):1591-605. doi: 10.2174/1389450116666151001113537.
Polysaccharides are natural polymers, obtained from a large variety of sources ranging from fungi to more complex organisms such as birds and whales. Their use for pharmaceutical and biomedical applications has been the subject of numerous researches by the world´s academia. Polysaccharide chemical/physical modifications leading to graft copolymers are discussed in this review, focusing on those nanosystems that are potential candidates for drug delivery applications. Therefore, this review focuses on the biomedical application of polysaccharide based copolymers, particularly as nanocarriers. Copolymer of polysaccharides such as alginate, cellulose, chitosan, dextran, guar, hyaluronic acid, pullulan and starch as drug delivery nanocarriers will be discussed.
多糖是天然聚合物,其来源广泛,从真菌到鸟类和鲸鱼等更复杂的生物体都有。多糖在制药和生物医学领域的应用一直是全球学术界众多研究的主题。本综述讨论了导致接枝共聚物的多糖化学/物理修饰,重点关注那些有望用于药物递送应用的纳米系统。因此,本综述聚焦于基于多糖的共聚物在生物医学领域的应用,尤其是作为纳米载体的应用。将讨论诸如藻酸盐、纤维素、壳聚糖、葡聚糖、瓜尔胶、透明质酸、支链淀粉和淀粉等多糖作为药物递送纳米载体的共聚物。