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从干细胞到法庭:DNA甲基化、法医表观基因组与生物社会档案的可能性

From stem cells to the law courts: DNA methylation, the forensic epigenome and the possibility of a biosocial archive.

作者信息

Relton Caroline L, Hartwig Fernando Pires, Davey Smith George

机构信息

MRC Integrative Epidemiology Unit, School of Social & Community Medicine, University of Bristol, Bristol, UK

Epidemiology Division, Federal University of Pelotas, Pelotas, Brazil.

出版信息

Int J Epidemiol. 2015 Aug;44(4):1083-93. doi: 10.1093/ije/dyv198.

Abstract

The growth in epigenetics continues to attract considerable cross-disciplinary interest, apparently representing an opportunity to move beyond genomics towards the goal of understanding phenotypic variability from molecular through organismal to the societal level. The epigenome may also harbour useful information about life-time exposures (measured or unmeasured) irrespective of their influence on health or disease, creating the potential for a person-specific . Furthermore such data may prove of use in providing identifying information, providing the possibility of a future . The mechanisms involved in ensuring that environmentally induced epigenetic changes perpetuate across the life course remain unclear. Here we propose a potential role of in maintaining epigenetic states provides a useful basis for formulating such epidemiologically-relevant concepts.

摘要

表观遗传学的发展持续吸引着大量跨学科关注,显然这代表着一个超越基因组学的机会,朝着从分子层面到机体层面再到社会层面理解表型变异的目标迈进。表观基因组也可能包含有关终身暴露(已测量或未测量)的有用信息,无论这些暴露对健康或疾病有无影响,这就产生了针对个人的可能性。此外,此类数据可能在提供识别信息方面有用,为未来提供了可能性。确保环境诱导的表观遗传变化在整个生命过程中持续存在的机制仍不清楚。在这里,我们提出在维持表观遗传状态方面的潜在作用为制定此类与流行病学相关的概念提供了有用的基础。

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