B细胞在自身免疫、感染和癌症中的调节作用：超越白细胞介素10产生的视角
The regulatory role of B cells in autoimmunity, infections and cancer: Perspectives beyond IL10 production.
作者信息
Gorosito Serrán Melisa, Fiocca Vernengo Facundo, Beccaria Cristian G, Acosta Rodriguez Eva V, Montes Carolina L, Gruppi Adriana
机构信息
Centro de Investigaciones en Bioquímica Clínica e Inmunología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
Centro de Investigaciones en Bioquímica Clínica e Inmunología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
出版信息
FEBS Lett. 2015 Nov 14;589(22):3362-9. doi: 10.1016/j.febslet.2015.08.048. Epub 2015 Sep 28.
The term regulatory B cells (B regs) is ascribed to a heterogeneous population of B cells with the function of suppressing inflammatory responses. They have been described mainly during the last decade in the context of different immune-mediated diseases. Most of the work on B regs has been focused on IL-10-producing B cells. However, B cells can exert regulatory functions independently of IL-10 production. Here we discuss the phenotypes, development and effector mechanisms of B regs and advances in their role in autoimmunity, infections and cancer.
调节性B细胞（Bregs）这一术语用于描述具有抑制炎症反应功能的异质性B细胞群体。在过去十年中，主要是在不同的免疫介导疾病背景下对它们进行了描述。关于Bregs的大多数研究工作都集中在产生白细胞介素-10（IL-10）的B细胞上。然而，B细胞可以独立于IL-10的产生发挥调节功能。在此，我们讨论Bregs的表型、发育和效应机制，以及它们在自身免疫、感染和癌症中的作用进展。
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