Sarkar Debashis, Kumar Manal
Department of MSc Advanced Surgical Practice, Cardiff University, Cardiff, UK Department of Urology, Wirral University Hospital, Wirral, UK.
Department of Urology, Wirral University Hospital, Wirral, UK.
BMJ Case Rep. 2015 Sep 30;2015:bcr2015211576. doi: 10.1136/bcr-2015-211576.
A 70-year-old man underwent a laparoscopic radical prostatectomy with preservation of bladder neck for T3aN0R0 prostate cancer in December 2009, (Gleason 4+3, negative surgical margin). His postoperative prostate-specific antigen rose from 0.01 to 0.05 ng/mL over 19 months. He had salvage radiotherapy in May 2012. Following radiotherapy, his urinary control worsened and he needed to wear up to four pads per day. He was being considered for an artificial urinary sphincter placement. He was also taking doxazosin for hypertension, which was discontinued. After stopping the doxazosin, his urinary control improved and he did not require any further intervention. Doctors should be aware of the effect of α-blockers on the internal sphincter and the risk of incontinence in patients post-prostate cancer treatment.
一名70岁男性于2009年12月接受了腹腔镜下根治性前列腺切除术，保留膀胱颈，用于治疗T3aN0R0前列腺癌（Gleason评分4+3，手术切缘阴性）。术后19个月，他的前列腺特异性抗原从0.01升至0.05 ng/mL。2012年5月他接受了挽救性放疗。放疗后，他的尿控能力恶化，每天需要使用多达4片尿垫。当时正在考虑为他植入人工尿道括约肌。他还因高血压服用多沙唑嗪，后来停药。停用多沙唑嗪后，他的尿控能力有所改善，无需进一步干预。医生应了解α受体阻滞剂对尿道内括约肌的影响以及前列腺癌治疗后患者发生尿失禁的风险。
