missMethyl：一个用于分析 Illumina 人类甲基化 450 平台数据的 R 包。
missMethyl: an R package for analyzing data from Illumina's HumanMethylation450 platform.
机构信息
Bioinformatics Group, Murdoch Childrens Research Institute, Royal Children's Hospital, 50 Flemington Road, Parkville, Victoria, 3052, Australia.
出版信息
Bioinformatics. 2016 Jan 15;32(2):286-8. doi: 10.1093/bioinformatics/btv560. Epub 2015 Sep 30.
UNLABELLED
DNA methylation is one of the most commonly studied epigenetic modifications due to its role in both disease and development. The Illumina HumanMethylation450 BeadChip is a cost-effective way to profile >450 000 CpGs across the human genome, making it a popular platform for profiling DNA methylation. Here we introduce missMethyl, an R package with a suite of tools for performing normalization, removal of unwanted variation in differential methylation analysis, differential variability testing and gene set analysis for the 450K array.
AVAILABILITY AND IMPLEMENTATION
missMethyl is an R package available from the Bioconductor project at www.bioconductor.org.
CONTACT
SUPPLEMENTARY INFORMATION
Supplementary data are available at Bioinformatics online.
未加标签
DNA 甲基化是最常研究的表观遗传修饰之一，因为它在疾病和发育中都有作用。Illumina HumanMethylation450 BeadChip 是一种经济有效的方法，可以对人类基因组中超过 450000 个 CpG 进行分析，使其成为 DNA 甲基化分析的流行平台。在这里，我们介绍了 missMethyl，这是一个 R 包，具有一套用于 450K 阵列进行标准化、去除差异甲基化分析中不需要的变异性、差异变异性测试和基因集分析的工具。
可用性和实现
missMethyl 是一个 R 包，可在 Bioconductor 项目中获得，网址为 www.bioconductor.org。
联系人
补充信息
补充数据可在Bioinformatics 在线获得。
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