Department of Biostatistics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Bioinformatics. 2012 Mar 1;28(5):729-30. doi: 10.1093/bioinformatics/bts013. Epub 2012 Jan 16.
The Illumina Infinium HumanMethylation450 BeadChip is a newly designed high-density microarray for quantifying the methylation level of over 450 000 CpG sites within human genome. Illumina Methylation Analyzer (IMA) is a computational package designed to automate the pipeline for exploratory analysis and summarization of site-level and region-level methylation changes in epigenetic studies utilizing the 450K DNA methylation microarray. The pipeline loads the data from Illumina platform and provides user-customized functions commonly required to perform exploratory methylation analysis for individual sites as well as annotated regions.
IMA is implemented in the R language and is freely available from http://www.rforge.net/IMA.
Illumina Infinium HumanMethylation450 BeadChip 是一种新设计的高密度微阵列，用于定量检测人类基因组中超过 450000 个 CpG 位点的甲基化水平。Illumina Methylation Analyzer（IMA）是一个计算包，旨在为利用 450K DNA 甲基化微阵列进行表观遗传学研究中的位点和区域水平甲基化变化的探索性分析和总结自动完成流水线。该流水线从 Illumina 平台加载数据，并提供用户自定义的功能，通常需要对单个位点以及注释区域执行探索性甲基化分析。
IMA 是用 R 语言实现的，并可从 http://www.rforge.net/IMA 免费获得。
