有氧糖酵解作为肿瘤侵袭性的标志物：高级别人类脑肿瘤的初步数据
Aerobic Glycolysis as a Marker of Tumor Aggressiveness: Preliminary Data in High Grade Human Brain Tumors.
作者信息
Vlassenko Andrei G, McConathy Jonathan, Couture Lars E, Su Yi, Massoumzadeh Parinaz, Leeds Hayden S, Chicoine Michael R, Tran David D, Huang Jiayi, Dahiya Sonika, Marcus Daniel S, Fouke Sarah Jost, Rich Keith M, Raichle Marcus E, Benzinger Tammie L S
机构信息
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
出版信息
Dis Markers. 2015;2015:874904. doi: 10.1155/2015/874904. Epub 2015 Sep 3.
OBJECTIVES
Glucose metabolism outside of oxidative phosphorylation, or aerobic glycolysis (AG), is a hallmark of active cancer cells that is not directly measured with standard (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET). In this study, we characterized tumor regions with elevated AG defined based on PET measurements of glucose and oxygen metabolism.
METHODS
Fourteen individuals with high-grade brain tumors underwent structural MR scans and PET measurements of cerebral blood flow (CBF), oxygen (CMRO2) and glucose (CMRGlu) metabolism, and AG, using (15)O-labeled CO, O2 and H2O, and FDG, and were compared to a normative cohort of 20 age-matched individuals.
RESULTS
Elevated AG was observed in most high-grade brain tumors and it was associated with decreased CMRO2 and CBF, but not with significant changes in CMRGlu. Elevated AG was a dramatic and early sign of tumor growth associated with decreased survival. AG changes associated with tumor growth were differentiated from the effects of nonneoplastic processes such as epileptic seizures.
CONCLUSIONS
Our findings demonstrate that high-grade brain tumors exhibit elevated AG as a marker of tumor growth and aggressiveness. AG may detect areas of active tumor growth that are not evident on conventional FDG PET.
目的
氧化磷酸化以外的葡萄糖代谢，即有氧糖酵解（AG），是活跃癌细胞的一个标志，而标准的（18）F-氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）无法直接测量。在本研究中，我们对基于葡萄糖和氧代谢的PET测量定义的AG升高的肿瘤区域进行了特征描述。
方法
14名患有高级别脑肿瘤的个体接受了结构磁共振扫描以及使用（15）O标记的CO、O2和H2O及FDG对脑血流量（CBF）、氧代谢（CMRO2）、葡萄糖代谢（CMRGlu）和AG进行的PET测量，并与20名年龄匹配的正常个体队列进行比较。
结果
在大多数高级别脑肿瘤中观察到AG升高，且其与CMRO2和CBF降低相关，但与CMRGlu的显著变化无关。AG升高是肿瘤生长的一个显著且早期的迹象，与生存率降低相关。与肿瘤生长相关的AG变化与癫痫发作等非肿瘤性过程的影响相区分。
结论
我们的研究结果表明，高级别脑肿瘤表现出AG升高，作为肿瘤生长和侵袭性的标志物。AG可能检测到传统FDG PET上不明显的活跃肿瘤生长区域。
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