带有氮杂环卡宾和双齿吡啶甲酸酯配体的潜在钌茚基催化剂。

Schmid Thibault E, Modicom Florian, Dumas Adrien, Borré Etienne, Toupet Loic, Baslé Olivier, Mauduit Marc

Ecole Nationale supérieure de chimie de rennes, UMR CNRS 6226, 11 Allée de Beaulieu, 35708, Rennes, cedex 7, France.

Institut de Physique de Rennes, Université de Rennes 1, CNRS, UMR 6251, Rennes Cedex, France.

Beilstein J Org Chem. 2015 Sep 3;11:1541-6. doi: 10.3762/bjoc.11.169. eCollection 2015.

A silver-free methodology was developed for the synthesis of unprecedented N-heterocyclic carbene ruthenium indenylidene complexes bearing a bidentate picolinate ligand. The highly stable (SIPr)(picolinate)RuCl(indenylidene) complex 4a (SIPr = 1,3-bis(2-6-diisopropylphenyl)imidazolidin-2-ylidene) demonstrated excellent latent behaviour in ring closing metathesis (RCM) reaction and could be activated in the presence of a Brønsted acid. The versatility of the catalyst 4a was subsequently demonstrated in RCM, cross-metathesis (CM) and enyne metathesis reactions.

开发了一种无银方法，用于合成前所未有的带有双齿吡啶甲酸酯配体的N-杂环卡宾钌茚基配合物。高度稳定的（SIPr）（吡啶甲酸酯）RuCl（茚基）配合物4a（SIPr = 1,3-双（2-6-二异丙基苯基）咪唑啉-2-亚基）在闭环复分解（RCM）反应中表现出优异的潜伏行为，并且可以在布朗斯台德酸存在下被活化。随后在RCM、交叉复分解（CM）和烯炔复分解反应中证明了催化剂4a的多功能性。