玻璃体黄斑粘连对年龄相关性黄斑变性的影响。
Effects of Vitreomacular Adhesion on Age-Related Macular Degeneration.
作者信息
Kang Eui Chun, Koh Hyoung Jun
机构信息
Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea.
出版信息
J Ophthalmol. 2015;2015:865083. doi: 10.1155/2015/865083. Epub 2015 Sep 3.
Abstract
Herein, we review the association between vitreomacular adhesion (VMA) and neovascular age-related macular degeneration (AMD). Meta-analyses have shown that eyes with neovascular AMD are twice as likely to have VMA as normal eyes. VMA in neovascular AMD may induce inflammation, macular traction, decrease in oxygenation, sequestering of vascular endothelial growth factor (VEGF), and other cytokines or may directly stimulate VEGF production. VMA may also interfere with the treatment effects of anti-VEGF therapy, which is the standard treatment for neovascular AMD, and releasing VMA can improve the treatment response to anti-VEGF treatment in neovascular AMD. We also reviewed currently available methods of relieving VMA.
摘要
在此，我们回顾了玻璃体黄斑粘连（VMA）与新生血管性年龄相关性黄斑变性（AMD）之间的关联。荟萃分析表明，患有新生血管性AMD的眼睛发生VMA的可能性是正常眼睛的两倍。新生血管性AMD中的VMA可能会引发炎症、黄斑牵引、氧合作用降低、血管内皮生长因子（VEGF）及其他细胞因子的隔离，或者可能直接刺激VEGF的产生。VMA还可能干扰抗VEGF治疗的效果，而抗VEGF治疗是新生血管性AMD的标准治疗方法，解除VMA可以改善新生血管性AMD对抗VEGF治疗的反应。我们还回顾了目前可用的缓解VMA的方法。
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