膳食肌肽对抑郁症可能具有的益处。
Possible Benefit of Dietary Carnosine towards Depressive Disorders.
作者信息
Hipkiss Alan R
机构信息
School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, U.K.
出版信息
Aging Dis. 2015 Oct 1;6(5):300-3. doi: 10.14336/AD.2014.1211. eCollection 2015 Sep.
Abstract
Many stress-related and depressive disorders have been shown to be associated with one or more of the following; shortened telomeres, raised cortisol levels and increased susceptibility to age-related dysfunction. It is suggested here that insufficient availability of the neurological peptide, carnosine, may provide a biochemical link between stress- and depression-associated phenomena: there is evidence that carnosine can enhance cortisol metabolism, suppress telomere shortening and exert anti-aging activity in model systems. Dietary supplementation with carnosine has been shown to suppress stress in animals, and improve behaviour, cognition and well-being in human subjects. It is therefore proposed that the therapeutic potential of carnosine dietary supplementation towards stress-related and depressive disorders should be examined.
摘要
许多与压力相关的和抑郁性疾病已被证明与以下一种或多种情况有关
端粒缩短、皮质醇水平升高以及对与年龄相关功能障碍的易感性增加。本文认为，神经肽肌肽的可用性不足可能在与压力和抑郁相关的现象之间提供一种生化联系：有证据表明，肌肽可以增强皮质醇代谢、抑制端粒缩短并在模型系统中发挥抗衰老活性。已证明在饮食中补充肌肽可减轻动物的压力，并改善人类受试者的行为、认知和幸福感。因此，有人提出应研究饮食补充肌肽对与压力相关的和抑郁性疾病的治疗潜力。
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