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醋酸格拉替雷用于治疗多发性硬化症引起的药物性肝损伤:一例报告

Drug-Induced Liver Injury by Glatiramer Acetate Used for Treatment of Multiple Sclerosis: A Case Report.

作者信息

Onmez Attila, Eminler Ahmet Tarik, Ergenç Hasan, Baykara Meltem, Uslan Ihsan, Tamer Ali

机构信息

Sakarya University Training and Research Hospital, Department of Internal Medicine, Sakarya.

Sakarya University Training and Research Hospital, Department of Gastroenterology, Sakarya.

出版信息

J Investig Med High Impact Case Rep. 2013 Dec 17;1(4):2324709613517493. doi: 10.1177/2324709613517493. eCollection 2013 Oct-Dec.

Abstract

Glatiramer acetate (GA, Copaxone) is an approved drug for the treatment of relapsing-remitting multiple sclerosis. Most common side effects observed with GA are local injection site reactions, which can include pain, swelling, or redness. However, systemic adverse event such as hepatotoxicity related to GA is rarely seen. In this report, we present a case of GA-induced toxic hepatitis associated with cholestatic and hepatocellular damage.

摘要

醋酸格拉替雷(GA,考帕松)是一种已获批准用于治疗复发缓解型多发性硬化症的药物。使用GA观察到的最常见副作用是局部注射部位反应,包括疼痛、肿胀或发红。然而,与GA相关的全身性不良事件如肝毒性很少见。在本报告中,我们介绍了一例与胆汁淤积和肝细胞损伤相关的GA诱导的中毒性肝炎病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff17/4528838/032b38678a55/10.1177_2324709613517493-fig1.jpg

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