Onmez Attila, Eminler Ahmet Tarik, Ergenç Hasan, Baykara Meltem, Uslan Ihsan, Tamer Ali
Sakarya University Training and Research Hospital, Department of Internal Medicine, Sakarya.
Sakarya University Training and Research Hospital, Department of Gastroenterology, Sakarya.
J Investig Med High Impact Case Rep. 2013 Dec 17;1(4):2324709613517493. doi: 10.1177/2324709613517493. eCollection 2013 Oct-Dec.
Glatiramer acetate (GA, Copaxone) is an approved drug for the treatment of relapsing-remitting multiple sclerosis. Most common side effects observed with GA are local injection site reactions, which can include pain, swelling, or redness. However, systemic adverse event such as hepatotoxicity related to GA is rarely seen. In this report, we present a case of GA-induced toxic hepatitis associated with cholestatic and hepatocellular damage.
醋酸格拉替雷(GA,考帕松)是一种已获批准用于治疗复发缓解型多发性硬化症的药物。使用GA观察到的最常见副作用是局部注射部位反应,包括疼痛、肿胀或发红。然而,与GA相关的全身性不良事件如肝毒性很少见。在本报告中,我们介绍了一例与胆汁淤积和肝细胞损伤相关的GA诱导的中毒性肝炎病例。