Kurata K, Fujimoto K, Sakata T
Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Metabolism. 1989 Jan;38(1):46-51. doi: 10.1016/0026-0495(89)90178-9.
The effects of 12-mumol doses of the glucose analogues glucosamine, 2-fluoroglucose, 2-chloroglucose, 2-deoxyglucose (which were modified at carbon 2 of the glucopyranose ring), 1-aminoglucose and 1-deoxyglucose (modified at carbon 1), on feeding behavior and plasma glucose, insulin, and glycerol were examined after infusion into the rat third cerebroventricle. Plasma glucose and glycerol levels were elevated by glucosamine or 1-aminoglucose. Plasma insulin levels were unchanged by these analogues. Feeding was induced in 62% to 87% of the rats tested after infusion of glucosamine, 2-fluoroglucose, 2-chloroglucose, 2-deoxyglucose, 1-aminoglucose, or 1-deoxyglucose (mean meal size in responding rats, 43.9, 25.8, 22.7, 16.0, 42.3, and 3.8 pellets, respectively). The order of potency to induce feeding was amino, halogen, and hydrogen groups. These data reinforced the concept that the potency of glucose analogues to induce feeding depends on substituents at carbon 1 and carbon 2 of the glucopyranose ring.
将12微摩尔剂量的葡萄糖类似物氨基葡萄糖、2-氟葡萄糖、2-氯葡萄糖、2-脱氧葡萄糖（在吡喃葡萄糖环的C2位进行了修饰）、1-氨基葡萄糖和1-脱氧葡萄糖（在C1位进行了修饰）注入大鼠第三脑室后，检测了它们对摄食行为以及血浆葡萄糖、胰岛素和甘油的影响。氨基葡萄糖或1-氨基葡萄糖可使血浆葡萄糖和甘油水平升高。这些类似物不会改变血浆胰岛素水平。在注入氨基葡萄糖、2-氟葡萄糖、2-氯葡萄糖、2-脱氧葡萄糖、1-氨基葡萄糖或1-脱氧葡萄糖后，62%至87%的受试大鼠出现摄食行为（反应性大鼠的平均餐量分别为43.9、25.8、22.7、16.0、42.3和3.8粒食丸）。诱导摄食的效力顺序为氨基、卤素和氢基团。这些数据强化了这样一种观念，即葡萄糖类似物诱导摄食的效力取决于吡喃葡萄糖环C1和C2位的取代基。
